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  4. 中国科学院地球与行星物理重点实验室
Effects of PEGylation on biomimetic synthesis of magnetoferritin nanoparticles

文献类型：期刊论文

作者Yang, Caiyun1,2,3; Cao, Changqian1,2; Cai, Yao1,2; Xu, Huangtao1,2,3; Zhang, Tongwei1,2; Pan, Yongxin1,2
刊名JOURNAL OF NANOPARTICLE RESEARCH
出版日期2017-03-09
卷号19期号:3
关键词Ferritin PEGylation Biomimetic synthesis Magnetic nanoparticles Biomedical applications
ISSN号1388-0764
DOI10.1007/s11051-017-3805-y
文献子类Article
英文摘要Recent studies have demonstrated that ferrimagnetic magnetoferritin nanoparticles are a promising novel magnetic nanomaterial in biomedical applications, including biocatalysis, imaging, diagnostics, and tumor therapy. Here we investigated the PEGylation of human H-ferritin (HFn) proteins and the possible influence on biomimetic synthesis of magnetoferritin nanoparticles. The outer surface of HFn proteins was chemically modified with different PEG molecular weights (PEG10K and PEG20K) and different modification ratios (HFn subunit: PEG20K = 1: 1, 1: 2, 1: 4). The PEGylated HFn proteins were used for biomimetic synthesis of ferrimagnetic magnetoferritin nanoparticles. We found that, compared with magnetoferritin using non-PEGylated HFn protein templates, the synthesized magnetoferritin using the PEGylated HFn protein templates possessed larger magnetite cores, higher magnetization and relaxivity values, and improved thermal stability. These results suggest that the PEGylation of H-ferritin may improve the biomineralization of magnetoferritin nanoparticles and enhance their biomedical applications.
WOS关键词HUMAN FERRITIN CAGES ; MAGNETIC NANOPARTICLES ; POLY(ETHYLENE GLYCOL) ; PROTEIN PEGYLATION ; THERMAL-STABILITY ; MOLECULAR-WEIGHT ; CONTRAST AGENTS ; CANCER-CELLS ; CHEMISTRY ; TRYPSIN
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000411836000002
出版者SPRINGER
资助机构National Natural Science Foundation of China(41621004 ; National Natural Science Foundation of China(41621004 ; Frontier Science Program of Chinese Academy of Sciences ; Frontier Science Program of Chinese Academy of Sciences ; 41330104 ; 41330104 ; 41574062) ; 41574062) ; National Natural Science Foundation of China(41621004 ; National Natural Science Foundation of China(41621004 ; Frontier Science Program of Chinese Academy of Sciences ; Frontier Science Program of Chinese Academy of Sciences ; 41330104 ; 41330104 ; 41574062) ; 41574062) ; National Natural Science Foundation of China(41621004 ; National Natural Science Foundation of China(41621004 ; Frontier Science Program of Chinese Academy of Sciences ; Frontier Science Program of Chinese Academy of Sciences ; 41330104 ; 41330104 ; 41574062) ; 41574062) ; National Natural Science Foundation of China(41621004 ; National Natural Science Foundation of China(41621004 ; Frontier Science Program of Chinese Academy of Sciences ; Frontier Science Program of Chinese Academy of Sciences ; 41330104 ; 41330104 ; 41574062) ; 41574062)
源URL[http://ir.iggcas.ac.cn/handle/132A11/61943]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
通讯作者Pan, Yongxin
作者单位1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Beijing, Peoples R China
2.Chinese Acad Sci, France China Biomineralizat & Nanostruct Lab, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Caiyun,Cao, Changqian,Cai, Yao,et al. Effects of PEGylation on biomimetic synthesis of magnetoferritin nanoparticles[J]. JOURNAL OF NANOPARTICLE RESEARCH,2017,19(3).
APA Yang, Caiyun,Cao, Changqian,Cai, Yao,Xu, Huangtao,Zhang, Tongwei,&Pan, Yongxin.(2017).Effects of PEGylation on biomimetic synthesis of magnetoferritin nanoparticles.JOURNAL OF NANOPARTICLE RESEARCH,19(3).
MLA Yang, Caiyun,et al."Effects of PEGylation on biomimetic synthesis of magnetoferritin nanoparticles".JOURNAL OF NANOPARTICLE RESEARCH 19.3(2017).

入库方式： OAI收割

来源：地质与地球物理研究所

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