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The Surface Modification of Ferritin and Its Applications

文献类型：期刊论文

作者Yang Caiyun1,2,3; Cao Changqian1,2; Cai Yao1,2,3; Zhang Tongwei1,2; Pan Yongxin1,2
刊名PROGRESS IN CHEMISTRY
出版日期2016
卷号28期号:1页码:91-102
关键词ferritin nano-materials surface modification application
DOI10.7536/PC150633
文献子类Review
英文摘要Ferritin is a spherical protein composed of 24 subunits with an outer diameter of 12 nm and inner cavity diameter of 8 nm. The inner cavity can accommodate up to 4500 iron atoms as an iron mineral core (ferrihydrite in original). This special architecture of ferritin makes it an ideal nanoscale biotemplate. With the modification of the protein shell and the transformation of the inner mineral core, researchers have developed series of multifunctional cancer diagnostic agents and drug delivery systems against tumors. Recent studies of ferritin modification have focused on: (1) interior modification to make the nucleation of ferritin more efficient; (2) exterior modification by connecting PEG or antibody on the protein shell to develop ferritin new functions; (3) modification of interface between subunits to control the self-assemble of ferritin. This review summarizes the recent advances in the surface modifications of ferritin. We firstly review the two different modified methods, the chemical modification and the biological modification, then, discuss the diverse applications with modified ferritin in biomedicine, diagnostics and nano electronics, and the existing problems in the surface modifications of ferritin. We propose that a way to develop novel functionalized ferritin-based nano-materials is to combine the chemical and biological means.
WOS关键词PROTEIN-CAGE NANOPARTICLES ; HYDROXYSULFOSUCCINIMIDE ACTIVE ESTERS ; HORSE SPLEEN APOFERRITIN ; HUMAN H-FERRITIN ; ESCHERICHIA-COLI ; CROSS-LINKING ; HIGH-RESOLUTION ; DRUG-DELIVERY ; MASS-SPECTROMETRY ; PEGYLATION
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000370995800010
资助机构CAS/SAFEA(KZCX2-YW-T10) ; CAS/SAFEA(KZCX2-YW-T10) ; National Natural Science Foundation of China(41330104 ; National Natural Science Foundation of China(41330104 ; R&D of Key Instruments and Technologies for Deep Resources Prospecting(ZDYZ2012-1-01-02) ; R&D of Key Instruments and Technologies for Deep Resources Prospecting(ZDYZ2012-1-01-02) ; 41204053) ; 41204053) ; CAS/SAFEA(KZCX2-YW-T10) ; CAS/SAFEA(KZCX2-YW-T10) ; National Natural Science Foundation of China(41330104 ; National Natural Science Foundation of China(41330104 ; R&D of Key Instruments and Technologies for Deep Resources Prospecting(ZDYZ2012-1-01-02) ; R&D of Key Instruments and Technologies for Deep Resources Prospecting(ZDYZ2012-1-01-02) ; 41204053) ; 41204053)
源URL[http://ir.iggcas.ac.cn/handle/132A11/62064]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
作者单位1.Chinese Acad Sci, Inst Geol & Geophys, France China Biomineralizat & Nanostruct Lab, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yang Caiyun,Cao Changqian,Cai Yao,et al. The Surface Modification of Ferritin and Its Applications[J]. PROGRESS IN CHEMISTRY,2016,28(1):91-102.
APA Yang Caiyun,Cao Changqian,Cai Yao,Zhang Tongwei,&Pan Yongxin.(2016).The Surface Modification of Ferritin and Its Applications.PROGRESS IN CHEMISTRY,28(1),91-102.
MLA Yang Caiyun,et al."The Surface Modification of Ferritin and Its Applications".PROGRESS IN CHEMISTRY 28.1(2016):91-102.

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来源：地质与地球物理研究所

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