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Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children

文献类型：期刊论文

作者Wen, Hongwei1,3; Liu, Yue4; Rekik, Islem5; Wang, Shengpei1,3; Zhang, Jishui6; Zhang, Yue4; Peng, Yun4; He, Huiguang1,2,3; He HG(何晖光)
刊名HUMAN BRAIN MAPPING
出版日期2017-08-01
卷号38期号:8页码:3988-4008
关键词Tourette Syndrome Diffusion Mri Probabilistic Tractography Structural Network Graph Theory Topological Organization Multiple Kernel Learning
DOI10.1002/hbm.23643
文献子类Review
英文摘要Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder. Although previous TS studies revealed structural abnormalities in distinct corticobasal ganglia circuits, the topological alterations of the whole-brain white matter (WM) structural networks remain poorly understood. Here, we used diffusion MRI probabilistic tractography and graph theoretical analysis to investigate the topological organization of WM networks in 44 drug-naive TS children and 41 age- and gender-matched healthy children. The WM networks were constructed by estimating inter-regional connectivity probability and the topological properties were characterized using graph theory. We found that both TS and control groups showed an efficient small-world organization in WM networks. However, compared to controls, TS children exhibited decreased global and local efficiency, increased shortest path length and small worldness, indicating a disrupted balance between local specialization and global integration in structural networks. Although both TS and control groups showed highly similar hub distributions, TS children exhibited significant decreased nodal efficiency, mainly distributed in the default mode, language, visual, and sensorimotor systems. Furthermore, two separate networks showing significantly decreased connectivity in TS group were identified using network-based statistical (NBS) analysis, primarily composed of the parieto-occipital cortex, precuneus, and paracentral lobule. Importantly, we combined support vector machine and multiple kernel learning frameworks to fuse multiple levels of network topological features for classification of individuals, achieving high accuracy of 86.47%. Together, our study revealed the disrupted topological organization of structural networks related to pathophysiology of TS, and the discriminative topological features for classification are potential quantitative neuroimaging biomarkers for clinical TS diagnosis. Hum Brain Mapp 38:3988-4008, 2017. (c) 2017 Wiley Periodicals, Inc.
学科主题模式识别与智能系统
WOS关键词ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; VOXEL-BASED MORPHOMETRY ; MAJOR DEPRESSIVE DISORDER ; DEFAULT MODE NETWORK ; WHITE-MATTER ; MULTIPLE-SCLEROSIS ; BASAL GANGLIA ; GRAPH-THEORY ; SMALL-WORLD ; MICROSTRUCTURAL ABNORMALITIES
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000404963900016
资助机构National Natural Science Foundation of China(91520202 ; Youth Innovation Promotion Association CAS ; Beijing Municipal Administration of Hospitals Incubating Program(PX2016035) ; Beijing Health System Top Level Health Technical Personnel Training Plan(2015-3-082) ; 61271151 ; 31271161 ; 81671651)
源URL[http://ir.ia.ac.cn/handle/173211/14659]  
专题自动化研究所_复杂系统管理与控制国家重点实验室_影像分析与机器视觉团队
通讯作者He HG(何晖光)
作者单位1.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing, Peoples R China
2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, 56 Nanlishi Rd, Beijing 100045, Peoples R China
5.Univ Dundee, Sch Sci & Engn, CVIP, Comp, Dundee, Scotland
6.Capital Med Univ, Beijing Childrens Hosp, Dept Neurol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wen, Hongwei,Liu, Yue,Rekik, Islem,et al. Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children[J]. HUMAN BRAIN MAPPING,2017,38(8):3988-4008.
APA Wen, Hongwei.,Liu, Yue.,Rekik, Islem.,Wang, Shengpei.,Zhang, Jishui.,...&何晖光.(2017).Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children.HUMAN BRAIN MAPPING,38(8),3988-4008.
MLA Wen, Hongwei,et al."Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children".HUMAN BRAIN MAPPING 38.8(2017):3988-4008.

入库方式： OAI收割

来源：自动化研究所

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