Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
文献类型：期刊论文
| 作者 | Liu, Yue1 ; Wang, Jieqiong2,3; Zhang, Jishui4; Wen, Hongwei2,3; Zhang, Yue1; Kang, Huiying1; Wang, Xu4; Li, Wenfeng1; He, Huiguang2,3,5; Peng, Yun1
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-07-06 |
| 卷号 | 7 |
| DOI | 10.1038/s41598-017-04148-z |
| 文献子类 | Article |
| 英文摘要 | Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 21 drug-naive and pure TS children and 29 demographically matched healthy children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to measure spontaneous brain activity. We found significant alterations of ALFF or fALFF in vision-related structures including the calcarine sulcus, the cuneus, the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found in the right cerebellum. Further analysis showed that the ReHo value of the right cerebellum was positively correlated with TS duration. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the neurophysiological mechanism in TS children. Moreover, the right cerebellum can be potentially used as a biomarker for the pathophysiology of early TS in children. |
| WOS关键词 | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; OLD-WORLD MONKEY ; FUNCTIONAL CONNECTIVITY ; BASAL GANGLIA ; REGIONAL HOMOGENEITY ; TIC DISORDERS ; NETWORKS ; MRI ; ABNORMALITIES ; INSULA |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000404841100064 |
| 资助机构 | National Natural Science Foundation of China(81671651 ; Youth Innovation Promotion Association CAS ; Beijing Municipal Administration of Hospitals Incubating Program(PX2016035) ; Beijing health system top level health technical personnel training plan(2015-3-082) ; Beijing Municipal Science and Technology Project Support(Z161100000116050) ; 91520202) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/15253]  |
| 专题 | 自动化研究所_复杂系统管理与控制国家重点实验室_影像分析与机器视觉团队 |
| 作者单位 | 1.Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, Natl Ctr Childrens Hlth, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Capital Med Univ, Beijing Childrens Hosp, Dept Neurol, Natl Ctr Childrens Hlth, Beijing, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yue,Wang, Jieqiong,Zhang, Jishui,et al. Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Liu, Yue.,Wang, Jieqiong.,Zhang, Jishui.,Wen, Hongwei.,Zhang, Yue.,...&Peng, Yun.(2017).Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study.SCIENTIFIC REPORTS,7. |
| MLA | Liu, Yue,et al."Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：自动化研究所
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