Effect of surface properties on liposomal siRNA delivery
文献类型：期刊论文
| 作者 | Xia, Yuqiong1; Tian, Jie1,2 ; Chen, Xiaoyuan3
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 79期号:2015页码:56-68 |
| 关键词 | Sirna Delivery Liposomes Surface Charge Pegylation Ligand Modification |
| DOI | 10.1016/j.biomaterials.2015.11.056 |
| 文献子类 | Review |
| 英文摘要 | Liposomes are one of the most widely investigated carriers for siRNA delivery. The surface properties of liposomal carriers, including the surface charge, PEGylation, and ligand modification can significantly affect the gene silencing efficiency. Three barriers of systemic siRNA delivery (long blood circulation, efficient tumor penetration and efficient cellular uptake/endosomal escape) are analyzed on liposomal carriers with different surface charges, PEGylations and ligand modifications. Cationic formulations dominate siRNA delivery and neutral formulations also have good performance while anionic formulations are generally not proper for siRNA delivery. The PEG dilemma (prolonged blood circulation vs. reduced cellular uptake/endosomal escape) and the side effect of repeated PEGylated formulation (accelerated blood clearance) were discussed. Effects of ligand modification on cationic and neutral formulations were analyzed. Finally, we summarized the achievements in liposomal siRNA delivery, outlined existing problems and provided some future perspectives. Published by Elsevier Ltd. |
| WOS关键词 | SMALL INTERFERING RNA ; ACCELERATED BLOOD CLEARANCE ; CALCIUM-PHOSPHATE NANOPARTICLES ; LIPID-LIKE MATERIALS ; PEG IGM PRODUCTION ; IN-VIVO ; GENE DELIVERY ; CANCER-CELLS ; POLY(ETHYLENE GLYCOL) ; CATIONIC LIPOSOMES |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000368868400006 |
| 资助机构 | program of China Scholarships Council(1408260074) ; Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health |
| 源URL | [http://ir.ia.ac.cn/handle/173211/11336]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Tian, Jie |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA |
| 推荐引用方式 GB/T 7714 | Xia, Yuqiong,Tian, Jie,Chen, Xiaoyuan. Effect of surface properties on liposomal siRNA delivery[J]. BIOMATERIALS,2016,79(2015):56-68. |
| APA | Xia, Yuqiong,Tian, Jie,&Chen, Xiaoyuan.(2016).Effect of surface properties on liposomal siRNA delivery.BIOMATERIALS,79(2015),56-68. |
| MLA | Xia, Yuqiong,et al."Effect of surface properties on liposomal siRNA delivery".BIOMATERIALS 79.2015(2016):56-68. |
入库方式： OAI收割
来源：自动化研究所
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