Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer
文献类型：期刊论文
| 作者 | Sun, Mengmeng1; Liu, Fei1 ; Zhu, Yukun2; Wang, Wansheng1; Hu, Jin1; Liu, Jing1; Dai, Zhifei3,4; Wang, Kun2; Wei, Yen5; Bai, Jing1
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| 刊名 | NANOSCALE
 |
| 出版日期 | 2016 |
| 卷号 | 8期号:8页码:4452-4457 |
| DOI | 10.1039/c6nr00056h |
| 文献子类 | Article |
| 英文摘要 | The challenge in photothermal therapy (PTT) is to develop bio-compatible photothermal transducers that can absorb and convert near-infrared (NIR) light into heat with high efficiency. Herein, we report salt-induced aggregation of gold nanoparticles (GNPs) in biological media to form highly efficient and biocompatible NIR photothermal transducers for PTT and photothermal/photoacoustic (PT/PA) imaging of cancer. The GNP depots in situ formed by salt-induced aggregation of GNPs show strong NIR absorption induced by plasmonic coupling between adjacent GNPs and very high photothermal conversion efficiency (52%), enabling photothermal destruction of tumor cells. More interestingly, GNPs in situ aggregate in tumors to form GNP depots, enabling simultaneous PT/PA imaging and PTT of the tumors. These findings may provide a simple and effective way to develop a new class of intelligent and biocompatible NIR photothermal transducers with high efficiency for PT/PA imaging and PTT. |
| WOS关键词 | PH-INDUCED AGGREGATION ; IN-VIVO ; ORGANIC NANOPARTICLES ; ABLATION ; CELLS ; AGENT ; NANOVESICLES ; NANOSHEETS ; RESONANCE ; SELENIDE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000371117900004 |
| 资助机构 | National Natural Science Foundation of China(21274043 ; National Basic Research Program of China (973)(2011CB707701) ; 21534006 ; 81227901) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/11360]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Peking Univ, Coll Engn, Beijing 100871, Peoples R China 4.Peking Univ, Hosp 3, Beijing 100871, Peoples R China 5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Mengmeng,Liu, Fei,Zhu, Yukun,et al. Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer[J]. NANOSCALE,2016,8(8):4452-4457. |
| APA | Sun, Mengmeng.,Liu, Fei.,Zhu, Yukun.,Wang, Wansheng.,Hu, Jin.,...&Gao, Weiping.(2016).Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer.NANOSCALE,8(8),4452-4457. |
| MLA | Sun, Mengmeng,et al."Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer".NANOSCALE 8.8(2016):4452-4457. |
入库方式： OAI收割
来源：自动化研究所
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