White matter integrity in young smokers: a tract-based spatial statistics study
文献类型：期刊论文
| 作者 | Yu, Dahua1; Yuan, Kai3; Zhang, Baohua1; Liu, Jixin3; Dong, Minghao3; Jin, Chenwang4; Luo, Lin2; Zhai, Jinquan2; Zhao, Ling5; Zhao, Ying1 |
| 刊名 | ADDICTION BIOLOGY
 |
| 出版日期 | 2016-05-01 |
| 卷号 | 21期号:3页码:679-687 |
| 关键词 | Diffusion Tensor Imaging Smoking Tract-based Spatial Statistics |
| DOI | 10.1111/adb.12237 |
| 文献子类 | Article |
| 英文摘要 | Previous diffusion tensor imaging (DTI) studies revealed contradictory effects of smoking on fractional anisotropy (FA). Multiple DTI-derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of young smokers. Twenty-three young smokers and 22 age-, education- and gender-matched healthy non-smoking controls participated in this study. Tract-based spatial statistics was employed to investigate the WM microstructure in young smokers by integrating multiple indices, including FA, mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). Compared with healthy non-smoking controls, young smokers showed significantly increased FA with increased AD and decreased RD in several brain regions, while no difference in MD was observed. Specifically, the overlapped WM regions with increased FA, increased AD and decreased RD were found in the right posterior limb of the internal capsule, the right external capsule and the right superior corona radiata. Additionally, average FA and RD values in the WM regions mentioned earlier were significantly correlated with pack-years and Fagerstrom Test for Nicotine Dependence, while no correlation in AD was found. The WM tracts with increased FA may be more associated with RD, rather than AD in young smokers. We suggested that WM properties of several fibres in young smokers may be the biomarker as the cumulative effect and severity of nicotine dependence. |
| WOS关键词 | MICROSTRUCTURAL INTEGRITY ; CIGARETTE-SMOKING ; NICOTINE EXPOSURE ; ADOLESCENT BRAIN ; CORPUS-CALLOSUM ; TOBACCO-SMOKE ; DIFFUSION ; CORTEX ; MRI ; ABSTINENCE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Substance Abuse |
| 语种 | 英语 |
| WOS记录号 | WOS:000374486200013 |
| 资助机构 | Project for the National Key Basic Research and Development Program (973)(2014CB543203 ; National Natural Science Foundation of China(81301281 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(8002-72125760 ; Natural Science Foundation of Inner Mongolia(2012MS0908) ; China Post- doctoral Science Foundation(2014M552416) ; Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region ; 2011CB707700 ; 61179019 ; 8002-72135767 ; 2012CB518501) ; 81101036 ; 8002-72145760) ; 81101108 ; 81471737 ; 81473603 ; 81401488 ; 81460279 ; 61261028 ; 81401478 ; 81271644 ; 81271546 ; 81227901 ; 31200837 ; 81030027) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/12218]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Yu, Dahua |
| 作者单位 | 1.Inner Mongolia Univ Sci & Technol, Inner Mongolia Key Lab Pattern Recognit & Intelli, Sch Informat Engn, 7 Arden St, Baotou 014010, Inner Mongolia, Peoples R China 2.Inner Mongolia Univ Sci & Technol, Dept Med Imaging, Baotou Med Coll, Affiliated Hosp 1, Baotou 014010, Inner Mongolia, Peoples R China 3.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, 266 Xinglong Sect Xifeng Rd, Xian 710071, Shaanxi, Peoples R China 4.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Med Imaging, Xian, Peoples R China 5.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Peoples R China 6.Chinese Acad Sci, Inst Automat, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Dahua,Yuan, Kai,Zhang, Baohua,et al. White matter integrity in young smokers: a tract-based spatial statistics study[J]. ADDICTION BIOLOGY,2016,21(3):679-687. |
| APA | Yu, Dahua.,Yuan, Kai.,Zhang, Baohua.,Liu, Jixin.,Dong, Minghao.,...&Tian, Jie.(2016).White matter integrity in young smokers: a tract-based spatial statistics study.ADDICTION BIOLOGY,21(3),679-687. |
| MLA | Yu, Dahua,et al."White matter integrity in young smokers: a tract-based spatial statistics study".ADDICTION BIOLOGY 21.3(2016):679-687. |
入库方式： OAI收割
来源：自动化研究所
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