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Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle

文献类型：期刊论文

作者Zeng, Chaoting1,2; Shang, Wenting1,3; Liang, Xiaoyuan1,2; Liang, Xiao1,3; Chen, Qingshan1,2; Chi, Chongwei1,3; Du, Yang1,3; Fang, Chihua2; Tian, Jie1,3
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2016-11-02
卷号8期号:43页码:29232-29241
关键词Gold Nanospheres Indocyanine Green Computed Tomography Nir Fluorescence Imaging Photothermal Therapy Imaging-guided Therapy
DOI10.1021/acsami.6b06883
文献子类Article
英文摘要To improve patient outcome and decrease overall health-care costs, highly sensitive and precise detection of a tumor is required for its accurate diagnosis and efficient therapy; however, this remains a challenge when using conventional single mode imaging. Here, we successfully designed a near infrared (NIR)-response photothermal therapy (PTT) platform (Au@MSNs-ICG) for the location, diagnosis, and NIR/computer tomography (CT) bimodal imaging-guided PTT of tumor tissues, using gold (Au) nanospheres coated with indocyanine green (ICG)-loaded mesoporous silica nanoparticles (MSNs), which would have high sensitivity and precision. The nanoparticles (NPs) exhibited good monodispersity, fluorescence stability, biocompatibility, and NIR/CT signaling and had a preferable temperature response under MR laser irradiation in vitro or in vivo. Using a combination of NIR/CT imaging and PTT treatment, the tumor could be accurately positioned and thoroughly eradicated in vivo by Au@MSNs-ICG injection. Hence, the multifunctional NPs could play an important role in facilitating the accurate treatment of tumors in future clinical applications.
WOS关键词RAY-COMPUTED-TOMOGRAPHY ; TARGETED GOLD NANOPARTICLES ; NEGATIVE BREAST-CANCER ; LARGE-SCALE SYNTHESIS ; INDOCYANINE-GREEN ; IN-VIVO ; CONTRAST AGENTS ; MESOPOROUS SILICA ; MAGNETIC-RESONANCE ; LUNG-CANCER
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000387095300007
资助机构National Natural Science Foundation of China(81227901 ; National High Technology Research and Development Program of China (863 Program)(2012AA021105) ; Guangdong provincial science and technology plan projects(2014A020212647) ; Cultivation of Guangdong College Students' Scientific and Technological Innovation project ("Climbing Program" Special Funds)(pdjh2016b0103 ; 81501540 ; pdjh2016a0090) ; 61231004 ; U1401254 ; 61401462 ; 61501462 ; 81527805 ; 81470083)
源URL[http://ir.ia.ac.cn/handle/173211/13342]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, 253 Gongye Ave, Guangzhou 510280, Guangdong, Peoples R China
3.Beijing Key Lab Mol Imaging, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zeng, Chaoting,Shang, Wenting,Liang, Xiaoyuan,et al. Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(43):29232-29241.
APA Zeng, Chaoting.,Shang, Wenting.,Liang, Xiaoyuan.,Liang, Xiao.,Chen, Qingshan.,...&Tian, Jie.(2016).Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle.ACS APPLIED MATERIALS & INTERFACES,8(43),29232-29241.
MLA Zeng, Chaoting,et al."Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle".ACS APPLIED MATERIALS & INTERFACES 8.43(2016):29232-29241.

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来源：自动化研究所

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