In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography
文献类型：期刊论文
| 作者 | Hu, Zhenhua1,2 ; Zhao, Mingxuan3; Qu, Yawei4; Zhang, Xiaojun5; Zhang, Mingru3; Liu, Muhan1; Guo, Hongbo1; Zhang, Zeyu1; Wang, Jing3; Yang, Weidong3
|
| 刊名 | JOURNAL OF NUCLEAR MEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 58期号:1页码:169-174 |
| 关键词 | Radiopharmaceutical Excitation Fluorescence Tomography (Reft) Cerenkov Luminescence Imaging (Cli) Radionuclides Hepatocellular Carcinoma (Hcc) Pet |
| DOI | 10.2967/jnumed.116.180596 |
| 文献子类 | Article |
| 英文摘要 | Cerenkov luminescence imaging can image radiopharmaceuticals using a high-sensitivity charge-coupled device camera. However, Cerenkov luminescence emitted from the radiopharmaceuticals is weak and has low penetration depth in biologic tissues, which severely limits the sensitivity and accuracy of Cerenkov luminescence imaging. This study presents 3-dimensional (3D) radiophamiaceutical-excited fluorescence tomography (REFT) using europium oxide (EO) nanoparticles, which enhances the Cerenkov luminescence signal intensity, improves the penetration depth, and obtains more accurate 3D distribution of radiopharmaceuticals. Methods: The enhanced optical signals of various radiopharmaceuticals (including F-18-FDG, (GaCl3)-Ga-68, Na(99)mTcO(4)) by EO nanoparticles were detected in vitro. The location and 3D distribution of the radiopharmaceuticals of REFT were then reconstructed and compared with those of Cerenkov luminescence tomography through the experiments with the phantom, artificial source-implanted mouse models, and mice bearing hepatocellular carcinomas. Results: The mixture of (GaCl3)-Ga-68 and EO nanoparticles possessed the strongest optical signals compared with the other mixtures. The in vitro phantom and implanted mouse studies showed that REFT revealed more accurate 3D distribution of (GaCl3)-Ga-68. REFT can detect more tumors than small-animal PET in hepatocellular carcinoma-bearing mice and achieved more accurate 3D distribution information than Cerenkov luminescence tomography. Conclusion: REFT with EO nanoparticles significantly improves accuracy of localization of radiopharmaceuticals and can precisely localize the tumor in vivo. |
| WOS关键词 | CERENKOV LUMINESCENCE TOMOGRAPHY ; MOUSE MODEL ; RADIONUCLIDE ; ENDOSCOPY |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000391343400036 |
| 资助机构 | National Natural Science Foundation of China(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; Beijing Municipal Science and Technology Commission(Z151100001615012) ; 81371594 ; 61231004 ; 81527805 ; 61302024 ; 81230033 ; 81471700) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/13387]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China 4.Gen Hosp Chinese Armed Police Forces, Dept Gastroenterol, Beijing, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Zhenhua,Zhao, Mingxuan,Qu, Yawei,et al. In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography[J]. JOURNAL OF NUCLEAR MEDICINE,2017,58(1):169-174. |
| APA | Hu, Zhenhua.,Zhao, Mingxuan.,Qu, Yawei.,Zhang, Xiaojun.,Zhang, Mingru.,...&Tian, Jie.(2017).In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography.JOURNAL OF NUCLEAR MEDICINE,58(1),169-174. |
| MLA | Hu, Zhenhua,et al."In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography".JOURNAL OF NUCLEAR MEDICINE 58.1(2017):169-174. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。