Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging
文献类型：期刊论文
| 作者 | Li, Na1 ; Wang, Jia-Bo2; Zhao, Yan-Ling2; Zhang, Lin2; Ma, Xi-Bo3; Li, Xiao-Fei2; Song, Jie1; Yang, Xin3; Xiao, Xiao-He2; Tian, Jie3
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACOLOGY
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| 出版日期 | 2017 |
| 卷号 | 13期号:2页码:175-182 |
| 关键词 | Emodin Hepatoprotection Reactive Oxygen Species Molecular Imaging Lipopolysaccharide Nuclear Factor Kappa b Anti-oxidation Alanine Aminotransferase Aspartate Transaminase |
| DOI | 10.3923/ijp.2017.175.182 |
| 文献子类 | Article |
| 英文摘要 | Background: Hepatocytes damage is sometimes closely related to oxidative stress and reactive oxygen species which are the major contributors to lipopolysaccharide-induced liver injury. Emodin, the active natural product in rhubarb of hydroxyanthraquinone skeleton, has been reported of protective activity to liver tissue, whose mechanism is generally thought of antioxidation based on chemical reaction or indirect evidence. There is no visualized evidence proved the reactive oxygen species scavenging effect of emodin in vivo. Materials and Methods: The dynamic reactive oxygen species luminescent signal in mice injured by bacillus calmette guerin and lipopolysaccharide was monitored by using the optical molecular imaging approach. Results: The elevations of serum alanine aminotransferase and aspartate transaminase activities in bacillus calmette guerin/lipopolysaccharide-injured mice were reversed by emodin, indicating the protection of emodin to hepatocytes. And emodin significantly and dose-dependently attenuated the reactive oxygen species luminescent signal elicited by bacillus calmette guerin/lipopolysaccharide, indicating visually the in vivo reactive oxygen species scavenging effect of emodin. In addition, emodin significantly and dose-dependently elevated the activity of superoxide dismutase, content of reduced glutathione and total antioxidant capacity and meanwhile decreased the contents of hydrogen peroxide, lipid peroxides and malondialdehyde in livers of bacillus calmette guerin/lipopolysaccharide-injured mice. It could be attributed to the anti-oxidative effect of emodin which helps to maintain the reactive oxygen species balance in vivo. Conclusion: Emodin can protect liver against bacillus calmette guerin/lipopolysaccharide-induced injury and the mechanism includes reactive oxygen species scavenging effect and anti-lipid peroxidation at least. |
| WOS关键词 | IN-VIVO ; OXIDATIVE STRESS ; TNF-ALPHA ; LIPID-PEROXIDATION ; KAPPA-B ; RATS ; DAMAGE ; ACTIVATION ; ROS ; INFLAMMATION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000392882700007 |
| 资助机构 | National Natural Science Foundation of China(81373984 ; National Industry Program of China(201207002) ; National Key Technology R and D Program(2012BAI29B02 ; 81274026 ; 206030201) ; 30572336) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/14367]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Liaoning, Peoples R China 2.302 Mil Hosp, Integrat Med Ctr, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Na,Wang, Jia-Bo,Zhao, Yan-Ling,et al. Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging[J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY,2017,13(2):175-182. |
| APA | Li, Na.,Wang, Jia-Bo.,Zhao, Yan-Ling.,Zhang, Lin.,Ma, Xi-Bo.,...&Kang, Ting-Guo.(2017).Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging.INTERNATIONAL JOURNAL OF PHARMACOLOGY,13(2),175-182. |
| MLA | Li, Na,et al."Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging".INTERNATIONAL JOURNAL OF PHARMACOLOGY 13.2(2017):175-182. |
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来源：自动化研究所
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