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Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas

文献类型：期刊论文

作者Bai, Yan1,2; Lin, Yusong3,4; Zhang, Wei5; Kong, Lingfei2,6; Wang, Lifu2,6; Zuo, Panli7; Vallines, Ignacio8; Schmitt, Benjamin9; Tian, Jie10; Song, Xiaolei11
刊名ONCOTARGET
出版日期2017
卷号8期号:4页码:5834-5842
关键词Amide Proton Transfer Glioma Grading Ki-67 Magnetic Resonance Imaging
DOI10.18632/oncotarget.13970
文献子类Article
英文摘要Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study. We compared the capability of amide proton transfer magnetic resonance imaging with that of noninvasive diffusion-weighted imaging and noninvasive 3-dimensional pseudo-continuous arterial spin imaging in evaluating the grading and cellularity of gliomas. Our results reveal that amide proton transfer magnetic resonance imaging is a superior imaging technique to diffusion-weighted imaging and 3-dimensional pseudo-continuous arterial spin imaging in the grading of gliomas. In addition, our results showed that the Ki-67 index correlated better with the amide proton transfer-weighted signal intensity than with the apparent diffusion coefficient value or the cerebral blood flow value in the gliomas. Amide proton transfer magnetic resonance imaging is a promising method for predicting the grading and cellularity of gliomas.
WOS关键词APPARENT DIFFUSION-COEFFICIENT ; HISTOGRAM ANALYSIS ; PERFUSION ; TUMOR ; CONTRAST ; PROLIFERATION ; SPECTROSCOPY ; GADOLINIUM ; MRI
WOS研究方向Oncology ; Cell Biology
语种英语
WOS记录号WOS:000393289000036
资助机构National Natural Science Foundation of China(81271565 ; National Institutes of Health(R21-EB020905-01A1) ; Henan Province Scientific and Technological Innovation Talents Project(164200510014) ; Cooperation Project(152106000014) ; Key Project of Henan Medical Science and Technology Project(201501011) ; 31470047 ; 81601466)
源URL[http://ir.ia.ac.cn/handle/173211/14375]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Zhengzhou Univ, Dept Radiol, Peoples Hosp, Zhengzhou, Henan, Peoples R China
2.Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China
3.Zhengzhou Univ, Cooperat Innovat Ctr Internet Healthcare, Zhengzhou, Henan, Peoples R China
4.Zhengzhou Univ, Sch Software & Appl Technol, Zhengzhou, Henan, Peoples R China
5.Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Radiol, Shanghai, Peoples R China
6.Zhengzhou Univ, Dept Pathol, Peoples Hosp, Zhengzhou, Henan, Peoples R China
7.Siemens Healthcare China, MR Collaborat NE Asia, Beijing, Peoples R China
8.Siemens Healthcare China, MR Collaborat NE Asia, Shanghai, Peoples R China
9.Siemens Healthcare Australia, Imaging & Therapy Syst Div, Brisbane, Qld, Australia
10.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Bai, Yan,Lin, Yusong,Zhang, Wei,et al. Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas[J]. ONCOTARGET,2017,8(4):5834-5842.
APA Bai, Yan.,Lin, Yusong.,Zhang, Wei.,Kong, Lingfei.,Wang, Lifu.,...&Wang, Meiyun.(2017).Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas.ONCOTARGET,8(4),5834-5842.
MLA Bai, Yan,et al."Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas".ONCOTARGET 8.4(2017):5834-5842.

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来源：自动化研究所

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