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Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo

文献类型：期刊论文

作者Zhan, Yonghua1; Cao, Xu1; Cao, Xin1; Li, Yingchao1; Tian, Jie2; Liang, Jimin1; Chen, Xueli1
刊名JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
出版日期2017-02-01
卷号13期号:2页码:144-154
关键词Near-infrared Heptamethine Dye Cross-linked Silica Fluorescence Optical Imaging
DOI10.1166/jbn.2017.2332
文献子类Article
英文摘要IR-780 iodide, a near-infrared (NIR) fluorescent heptamethine dye, has attracted wide attention in the biomedical community. However, hydrophobicity and toxicity severely limit its further biomedical application. Although many successful efforts have been made to increase its solubility and biocompatibility, a strong fluorescent signal and longer retention time are in high demand in biomedical application in vivo as well as basic science research. In this work, we report the development of novel silica cross-linked micellar core-shell nanoparticles encapsulating IR-780 (NIR-Silica NPs) and their utility for biomedical imaging in vivo. Compared to free IR-780, the solubility of NIR-Silica NPs was not only greatly increased, but there was also a dramatic 5-7-fold enhancement of fluorescence intensity. More importantly, the exceptionally small size (25 nm) and colloidal stability of the NPs are also sufficient to realize the enhanced permeability and retention effect. In vitro cell viability assays further indicated that the NIR-Silica NPs are safer even at the highest concentration tested of 1.0 mg/mL. Finally, sentinel lymph node mapping and long-term tumor imaging in vivo demonstrated that the NIR-Silica NPs have a long circulation time and higher signal-to-noise ratio at a very low dye concentration and short exposure time (0.2 s). Therefore, the NIR-Silica NPs may be a promising fluorescence imaging agent for clinical application.
WOS关键词BLOCK-COPOLYMER MICELLES ; INDOCYANINE GREEN ; DRUG-DELIVERY ; PHOTOTHERMAL THERAPY ; CANCER-THERAPY ; POLYMERIC MICELLES ; DYE ; AGENT ; VITRO
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000397028800003
资助机构Program of National Basic Research and Development Program of China (973)(2011CB707702) ; National Natural Science Foundation of China(81101100 ; Natural Science Basic Research Plan in Shaanxi Province of China(2015JQ6249) ; Fundamental Research Funds for the Central Universities(NSIZ021402 ; 81227901 ; NSIY061406) ; 81571725 ; 81230033 ; 81090272 ; 81101083 ; 31371006 ; 61405149 ; 81401442)
源URL[http://ir.ia.ac.cn/handle/173211/14436]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zhan, Yonghua,Cao, Xu,Cao, Xin,et al. Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2017,13(2):144-154.
APA Zhan, Yonghua.,Cao, Xu.,Cao, Xin.,Li, Yingchao.,Tian, Jie.,...&Chen, Xueli.(2017).Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,13(2),144-154.
MLA Zhan, Yonghua,et al."Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 13.2(2017):144-154.

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来源：自动化研究所

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