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Fast in vivo bioluminescence tomography using a novel pure optical imaging technique

文献类型：期刊论文

作者Zhang, Shuang1; Leng, Chengcai2; Liu, Hongbo2; Wang, Kun2; Tian, Jie2
刊名JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
出版日期2017-05-01
卷号10期号:3
关键词Optical Surface Reconstruction Bioluminescence Tomography Reconstruction Optical Molecular Imaging Light Flux Reconstruction
DOI10.1142/S1793545817500031
文献子类Article
英文摘要Bioluminescence tomography (BLT) is a novel optical molecular imaging technique that advanced the conventional planar bioluminescence imaging (BLI) into a quantifiable three-dimensional (3D) approach in preclinical living animal studies in oncology. In order to solve the inverse problem and reconstruct tumor lesions inside animal body accurately, the prior structural information is commonly obtained from X-ray computed tomography (CT). This strategy requires a complicated hybrid imaging system, extensive post imaging analysis and involvement of ionizing radiation. Moreover, the overall robustness highly depends on the fusion accuracy between the optical and structural information. Here, we present a pure optical bioluminescence tomographic (POBT) system and a novel BLT workflow based on multi-view projection acquisition and 3D surface reconstruction. This method can reconstruct the 3D surface of an imaging subject based on a sparse set of planar white-light and bioluminescent images, so that the prior structural information can be offered for 3D tumor lesion reconstruction without the involvement of CT. The performance of this novel technique was evaluated through the comparison with a conventional dual-modality tomographic (DMT) system and a commercialized optical imaging system (IVIS Spectrum) using three breast cancer xenografts. The results revealed that the new technique offered comparable in vivo tomographic accuracy with the DMT system (P > 0.05) in much shorter data analysis time. It also offered significantly better accuracy comparing with the IVIS system (P < 0.04) without sacrificing too much time.
WOS关键词RECONSTRUCTION ; MOUSE ; MODEL
WOS研究方向Optics ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000399088400008
资助机构National Basic Research Program of China (973 Program)(2015CB755500) ; National Natural Science Foundation of China(81227901 ; Scientific Research and Equipment Development Project of the Chinese Academy of Sciences(YZ201359) ; Key Research Program of the Chinese Academy of Sciences(KGZD-EW-T03) ; Chinese Academy of Sciences Fellowship for Young International Scientists(2013Y1GA0004) ; China Postdoctoral Science Foundation(2014M550881 ; 61231004 ; 2015T80155) ; 81527805 ; 61401462)
源URL[http://ir.ia.ac.cn/handle/173211/15087]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Northeastern Univ, Sinodutch Biomed & Informat Engn Sch, Shenyang 110819, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Shuang,Leng, Chengcai,Liu, Hongbo,et al. Fast in vivo bioluminescence tomography using a novel pure optical imaging technique[J]. JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,2017,10(3).
APA Zhang, Shuang,Leng, Chengcai,Liu, Hongbo,Wang, Kun,&Tian, Jie.(2017).Fast in vivo bioluminescence tomography using a novel pure optical imaging technique.JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,10(3).
MLA Zhang, Shuang,et al."Fast in vivo bioluminescence tomography using a novel pure optical imaging technique".JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES 10.3(2017).

入库方式： OAI收割

来源：自动化研究所

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