Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer
文献类型：期刊论文
| 作者 | Liu, Muhan1,2,3,4; Zheng, Sheng5; Zhang, Xiaojun6; Guo, Hongbo3,4,7; Shi, Xiaojing3,4,8 ; Kang, Xiaoyu9; Qu, Yawei5; Hu, Zhenhua3,4,8,10; Tian, Jie1,2,3,4,8
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| 刊名 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
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| 出版日期 | 2018 |
| 卷号 | 14期号:1页码:205-213 |
| 关键词 | Apoptosis Cerenkov Luminescence Imaging Vincristine-resistance Gastric Cancer Cisplatin |
| DOI | 10.1016/j.nano.2017.10.001 |
| 文献子类 | Article |
| 英文摘要 | Apoptosis imaging enables a timely and specific assessment of treatment response in cancer patients. In this study, we applied a probe for positron emission tomography (PET), which served as an optical biomaterial emitting Cerenkov photons, to in vivo optical imaging of tumor apoptosis, in order to evaluate early response to chemotherapy of drug-resistant gastric cancer. Ga-68-DOTA-Annexin V was prepared as the apoptosis targeting probe. Wild type human gastric adenocarcinoma cell line SGC7901/WT and drug vincristine-resistant variant SGC7901/VCR were used to establish normal and vincristine-resistant xenografts to simulate treatment decision situation. Vincristine-resistance of SGC7901/VCR and apoptosis-induction ability of vincristine and cisplatin were verified. In vitro and in vivo CLI of apoptosis was performed. Stronger signals of apoptosis of CLI correlated with confirmed higher levels of apoptosis and subsequent changes in tumor sizes. Our study suggests that CLI is a promising technique for in vivo imaging of apoptosis with radiopharmaceutical-labeled biomaterials. (C) 2017 Elsevier Inc. All rights reserved. |
| WOS关键词 | APOPTOSIS ; TOMOGRAPHY ; EMISSION ; MODEL ; RADIOTRACER ; MICE ; A5 |
| WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000423842300020 |
| 资助机构 | National Natural Science Foundation of China (NSFC)(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; Scientific Instrument Developing Project of the Chinese Academy of Sciences(YZ201672) ; 81527805 ; 61231004 ; 61622117 ; 81671759 ; 61302024) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/19549]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian, Shaanxi, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China 3.Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 4.Beijing Key Lab Mol Imaging, Beijing, Peoples R China 5.Chinese Peoples Armed Police Forces, Dept Gastroenterol, Gen Hosp, Beijing, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing, Peoples R China 7.Northwest Univ, Sch Informat Sci & Technol, Xian, Shaanxi, Peoples R China 8.Univ Chinese Acad Sci, Beijing, Peoples R China 9.Fourth Mil Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian, Shaanxi, Peoples R China 10.State Key Lab Management & Control Complex Syst, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Muhan,Zheng, Sheng,Zhang, Xiaojun,et al. Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2018,14(1):205-213. |
| APA | Liu, Muhan.,Zheng, Sheng.,Zhang, Xiaojun.,Guo, Hongbo.,Shi, Xiaojing.,...&Tian, Jie.(2018).Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,14(1),205-213. |
| MLA | Liu, Muhan,et al."Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 14.1(2018):205-213. |
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来源：自动化研究所
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