High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy
文献类型：期刊论文
| 作者 | Wei, Qiaolin1,2; Chen, Yao1; Ma, Xibo3 ; Ji, Jianfeng1; Qiao, Yue1,2; Zhou, Bo1,2; Ma, Fei2; Ling, Daishun4; Zhang, Hong1; Tian, Mei1
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2018-01-10 |
| 卷号 | 28期号:2页码:1704634 |
| 关键词 | Biodegradation Multimodal Imaging Nanoplatforms Renal Clearance Theranostics |
| DOI | 10.1002/adfm.201704634 |
| 文献子类 | Article |
| 英文摘要 | Renal-clearable nanoparticles have made it possible to overcome the toxicity by nonspecific accumulation in healthy tissues/ organs due to their highly efficient clearance characteristics. However, their tumor uptake is relatively low due to the short blood circulation time and rapid body elimination. Here, this problem is addressed by developing renal-clearable nanoparticles by controlled coating of sub-6 nm CuS nanodots (CuSNDs) on doxorubicin ladened mesoporous silica nanoparticles (pore size approximate to 6 nm) for multimodal application. High tumor uptake of the as-synthesized nanoparticles (abbreviated as MDNs) is achieved due to the longer blood circulation time. The MDNs also show excellent performance in bimodal imaging. Moreover, the MDNs demonstrated a photothermally sensitive drug release and pronounced synergetic effects of chemo-photothermal therapy, which were confirmed by two different tumor models in vivo. A novel key feature of the proposed synthesis is the use of renal-clearable CuSNDs and biodegradable mesoporous silica nanoparticles which also are renal-clearable after degradation. Therefore, the MDNs would be rapidly degraded and excreted in a reasonable period in living body and avoid long-term toxicity. Such biodegradable and clearable single-compartment theranostic agents applicable in highly integrated multimodal imaging and multiple therapeutic functions may have substantial potentials in clinical practice. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; CONTRAST AGENTS ; RENAL CLEARANCE ; DRUG-DELIVERY ; QUANTUM DOTS ; BIODISTRIBUTION ; TISSUE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000419454000013 |
| 资助机构 | National Key Research and Development Program of China(2016YFA0100900) ; National Key Basic Research Program of the China(2014CB744504) ; National Natural Science Foundation of China(81671748) ; Project of Chinese Thousand Youth Talents |
| 源URL | [http://ir.ia.ac.cn/handle/173211/19555]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Zhejiang Univ, Affiliated Hosp 2, Sch Med, PET Ctr,Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China 2.Zhejiang Univ, Inst Translat Med, Hangzhou 310009, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310009, Zhejiang, Peoples R China 5.Zhejiang Univ, Minist Educ, Key Lab Early Warning & Intervent Malignant Tumor, Hangzhou 310009, Zhejiang, Peoples R China 6.Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Qiaolin,Chen, Yao,Ma, Xibo,et al. High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(2):1704634. |
| APA | Wei, Qiaolin.,Chen, Yao.,Ma, Xibo.,Ji, Jianfeng.,Qiao, Yue.,...&Zhou, Min.(2018).High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,28(2),1704634. |
| MLA | Wei, Qiaolin,et al."High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS 28.2(2018):1704634. |
入库方式： OAI收割
来源：自动化研究所
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