中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 自动化研究所
  3. 中国科学院自动化研究所
  4. 中国科学院分子影像重点实验室
Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model

文献类型：期刊论文

作者Du, Yang1,2; Sun, Ting3; Liang, Xiaolong4; Li, Yuan3; Jin, Zhengyu3; Xue, Huadan3; Wan, Yihong5; Tian, Jie1,2
刊名INTERNATIONAL JOURNAL OF NANOMEDICINE
出版日期2017
卷号12期号:12页码:8337-8351
关键词Pd-1 Programmed Cell Death-1 Near-infrared Fluorescence (Nirf) Breast Cancer Image-guided Surgery Immunotherapy Fluorescence Imaging
DOI10.2147/IJN.S149235
文献子类Article
英文摘要An intraoperative technique to accurately identify microscopic tumor residuals could decrease the risk of positive surgical margins. Several lines of evidence support the expression and immunotherapeutie effect of PD-1 in breast cancer. Here, we sought to develop a fluorescence-labeled PD-1 probe for in vivo breast tumor imaging and image-guided surgery. The efficacy of PD-1 monoclonal antibody (PD-1 mAb) as adjuvant immunotherapy after surgery was also assessed. PD-1-I RDyc800CW was developed and examined for its application in tumor imaging and image-guided tumor resection in an immunocompetent 4T1 mouse tumor model. Fluorescence molecular imaging was performed to monitor probe biodistribution and intraoperative imaging. Bioluminescence imaging was performed to monitor tumor growth and evaluate postsurgical tumor residuals, recurrences, and metastases. The PD-1-IRDye800CW exhibited a specific signal at the tumor region compared with the IgG control. Furthermore, PD-1-IRDye800CW-guided surgery combined with PD-1 adjuvant immunotherapy inhibited tumor rcgrowth and microtumor metastases and thus improved survival rate. Our study demonstrates the feasibility of using PD-1-IRDye800CW for breast tumor imaging and image-guided tumor resection. Moreover, PD-1 mAb adjuvant immunotherapy reduces cancer recurrences and metastases emanating from tumor residuals.
WOS关键词CANCER-IMMUNOTHERAPY ; BREAST-CANCER ; ANTI-PD-L1 ANTIBODY ; ADVANCED MELANOMA ; SAFETY ; RESPONSES ; EXPRESSION ; BLOCKADE ; LYMPHOCYTES ; NIVOLUMAB
WOS研究方向Science & Technology - Other Topics ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000415814100002
资助机构National Natural Science Foundation of China(81227901 ; Research and Development Program of China (973)(2014CB748600 ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; Beijing Natural Science Foundation(Z16110200010000) ; Peking University Third Hospital(BYSY2015023) ; China Postdoctoral Science Foundation(2013M530014) ; Cancer Prevention Research Institute of Texas(RP130145) ; US Department of Defense(W81XWH-13-1-0318) ; Welch Foundation(1-1751) ; Mary Kay Foundation(073.14) ; 81470083 ; 2015CB755500) ; 81527805 ; 81571810 ; 61231004 ; 81771846 ; 81201186)
源URL[http://ir.ia.ac.cn/handle/173211/19584]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Radiol, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Ultrasound, Beijing, Peoples R China
5.Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
推荐引用方式
GB/T 7714		 Du, Yang,Sun, Ting,Liang, Xiaolong,et al. Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12(12):8337-8351.
APA Du, Yang.,Sun, Ting.,Liang, Xiaolong.,Li, Yuan.,Jin, Zhengyu.,...&Tian, Jie.(2017).Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model.INTERNATIONAL JOURNAL OF NANOMEDICINE,12(12),8337-8351.
MLA Du, Yang,et al."Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model".INTERNATIONAL JOURNAL OF NANOMEDICINE 12.12(2017):8337-8351.

入库方式： OAI收割

来源：自动化研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。