Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data
文献类型：期刊论文
| 作者 | Liu ZY(刘振宇)
|
| 刊名 | European Radiology
 |
| 出版日期 | 2017-10 |
| 期号 | 27页码:4153–4162 |
| 关键词 | Dti |
| 英文摘要 | ObjectiveTo identify the white matter (WM) impairments of the antiretroviral therapy (ART)-naïve HIV patients by conducting a multivariate pattern analysis (MVPA) of Diffusion Tensor Imaging (DTI) data MethodsWe enrolled 33 ART-naïve HIV patients and 32 Normal controls in the current study. Firstly, the DTI metrics in whole brain WM tracts were extracted for each subject and feed into the Least Absolute Shrinkage and Selection Operators procedure (LASSO)-Logistic regression model to identify the impaired WM tracts. Then, Support Vector Machines (SVM) model was constructed based on the DTI metrics in the impaired WM tracts to make HIV-control group classification. Pearson correlations between the WM impairments and HIV clinical statics were also investigated. ResultsExtensive HIV-related impairments were observed in the WM tracts associated with motor function, the corpus callosum (CC) and the frontal WM. With leave-one-out cross validation, accuracy of 83.08% (P=0.002) and the area under the Receiver Operating Characteristic curve of 0.9110 were obtained in the SVM classification model. The impairments of the CC were significantly correlated with the HIV clinic statics. ConclusionThe MVPA was sensitive to detect the HIV-related WM changes. Our findings indicated that the MVPA had considerable potential in exploring the HIV-related WM impairments. |
| 源URL | [http://ir.ia.ac.cn/handle/173211/20346]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu ZY. Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data[J]. European Radiology,2017(27):4153–4162. |
| APA | Liu ZY.(2017).Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data.European Radiology(27),4153–4162. |
| MLA | Liu ZY."Identifying the white matter impairments among ART-naïve HIV patients: a multivariate pattern analysis of DTI data".European Radiology .27(2017):4153–4162. |
入库方式： OAI收割
来源：自动化研究所
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