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Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe

文献类型：期刊论文

作者Jin, Yushen1,3; Wang, Kun1,3; Tian, Jie1,2,3,4
刊名BIOCONJUGATE CHEMISTRY
出版日期2018-04-01
卷号29期号:4页码:1475-1484
关键词Fluorescence Imaging Mri Hepatocellular Carcinoma Sp94 Peptide Imaging-guided Surgery
DOI10.1021/acs.bioconjchem.8b00161
文献子类Article
英文摘要In dinical imaging modalities, MRI is suitable for preoperative examination. Fluorescence imaging has been proposed to improve the detectability of cancer lesions during the operation. However, the specificity and accuracy of the two imaging modalities is limited. To improve the prognosis and survival rate of the patient suffering from hepatocellular carcinoma (HCC), it is very important to develop a specific probe to achieve early detection and precise resection of HCC. We selected HCC targeting peptide SP94 to conjugate with a NIR dye and Gd chelated DOTA to enhance the specificity of different imaging modalities. MRI and fluorescence imaging were used for preoperative examination of the cancer and detecting the tumor in the operation, respectively. MRI and fluorescence signals significantly increased when HCC occurs and the obtained probe shows high uptake in HCC but negligible uptake in the normal liver tissues. The signal-to-background ratio is higher than 2.23 (MRI) and 2.0 (fluorescence imaging) with noninvasive imaging modalities. After the intraperitoneal cavity was surgically exposed, the signal-to-background ratio is higher than 4.6. By combining the high specificity of our probe with the high sensitivity of fluorescence imaging, the microprimary malignancy and micrometastasis foci (diameter <1 mm) can be easily detected after the intraperitoneal cavity is exposed. These results indicated that our probe is conductive to the early detection and precise resection of the HCC and has the potential to improve the diagnosis and treatment of patients with HCC.
WOS关键词CLINICAL-APPLICATIONS ; OVARIAN-CANCER ; QUANTUM DOTS ; LIVER ; DELIVERY ; DIAGNOSIS ; NANOPARTICLES ; METASTASES ; THERAPY ; SURGERY
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000430641700070
资助机构National Key Research and Development Program of China(2017YFA0205200 ; National Natural Science Foundation of China(81701771 ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 2015CB755500 ; 81227901 ; 2016YFA0201401) ; 81527805 ; 61231004)
源URL[http://ir.ia.ac.cn/handle/173211/21692]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714		 Jin, Yushen,Wang, Kun,Tian, Jie. Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe[J]. BIOCONJUGATE CHEMISTRY,2018,29(4):1475-1484.
APA Jin, Yushen,Wang, Kun,&Tian, Jie.(2018).Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe.BIOCONJUGATE CHEMISTRY,29(4),1475-1484.
MLA Jin, Yushen,et al."Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe".BIOCONJUGATE CHEMISTRY 29.4(2018):1475-1484.

入库方式： OAI收割

来源：自动化研究所

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