Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Jin, Yushen1,2 ; Yang, Xin1,2; Tian, Jie1,2,3,4
|
| 刊名 | NANOSCALE
 |
| 出版日期 | 2018-05-28 |
| 卷号 | 10期号:20页码:9594-9601 |
| 关键词 | Polypyrrole Nanoparticles Photoacoustic And Near Infrared (Nir) Fluorescence Imaging Sp94 Peptide Hepatocellular Carcinoma Image-guided Photothermal Therapy |
| DOI | 10.1039/c8nr02036a |
| 文献子类 | Article |
| 英文摘要 | Early identification and treatment of hepatocellular carcinoma is very important for improving the prognosis and survival rate of the patient. To enhance the visualization and treatment efficiency of HCC, a theranostic agent has been developed that combines photoacoustic/fluorescence imaging with photothermal therapy for cancer. We report the synthesis of multifunctional theranostic SP94-modified polypyrrole (PPy)-BSA-ICG nanoparticles by a simple method. The multifunctional theranostic agent helped to combine two modes of imaging modalities, i.e. photoacoustic and near infrared (NIR) fluorescence imaging, together with photothermal therapy. These nanoparticles exhibited an excellent stability in physiological solutions (PBS, pH 7.4 at 37 degrees C), a higher tumor accumulation as compared to the unmodified nanoparticles, and minimal nonspecific uptake by other normal organs such as liver and spleen. Most importantly, the nanoparticles could effectively kill the tumor through photothermal therapy with no tumor recurrence upon a single laser irradiation event. These results indicate that SP94-modified PPy-BSA-ICG is potentially a promising theranostic agent for image-guided cancer therapy as it overcomes the limitations of each of the imaging modalities and thus improves the therapeutic efficiency and reduces the side effects. |
| WOS关键词 | GUIDED-PHOTOTHERMAL THERAPY ; THERANOSTIC AGENT ; INDOCYANINE GREEN ; GOLD NANOCAGES ; PRUSSIAN BLUE ; CUS NANOPARTICLES ; TANTALUM OXIDE ; DUAL-MODALITY ; CANCER ; FLUORESCENCE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000433260300019 |
| 资助机构 | National Key Research and Development Program of China(2017YFA0205200 ; National Natural Science Foundation of China(81227901 ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 2015CB755500 ; 81527805 ; 2016YFA0201401) ; 81701771 ; 61231004) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/21693]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Yushen,Yang, Xin,Tian, Jie. Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma[J]. NANOSCALE,2018,10(20):9594-9601. |
| APA | Jin, Yushen,Yang, Xin,&Tian, Jie.(2018).Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma.NANOSCALE,10(20),9594-9601. |
| MLA | Jin, Yushen,et al."Targeted polypyrrole nanoparticles for the identification and treatment of hepatocellular carcinoma".NANOSCALE 10.20(2018):9594-9601. |
入库方式： OAI收割
来源：自动化研究所
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