中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 自动化研究所
  3. 中国科学院自动化研究所
  4. 中国科学院分子影像重点实验室
Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd

文献类型：期刊论文

作者Ma, Xibo1; Jin, Yushen1; Wang, Yi1,2; Zhang, Shuai1,3; Peng, Dong1; Yang, Xin1; Wei, Shoushui3; Chai, Wei2; Li, Xuejun4; Tian, Jie1
刊名CONTRAST MEDIA & MOLECULAR IMAGING
出版日期2018
期号2018页码:9321862
关键词Multimodality Molecular Imaging Tumor Border Delineation Photothermal Therapy Hepatocellular Carcinoma
DOI10.1155/2018/9321862
文献子类Article
英文摘要Tumor cell complete extinction is a crucial measure to evaluate antitumor efficacy. The difficulties in defining tumor margins and finding satellite metastases are the reason for tumor recurrence. A synergistic method based on multimodality molecular imaging needs to be developed so as to achieve the complete extinction of the tumor cells. In this study, graphene oxide conjugated with gold nanostars and chelated with Gd through 1,4,7,10-tetraazacyclododecane-N, N', N, N'-tetraacetic acid (DOTA) (GO-AuNS-DOTA-Gd) were prepared to target HCC-LM3-fLuc cells and used for therapy. For subcutaneous tumor, multimodality molecular imaging including photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) and the related processing techniques were used to monitor the pharmacokinetics process of GO-AuNS-DOTA-Gd in order to determine the optimal time for treatment. For orthotopic tumor, MRI was used to delineate the tumor location and margin in vivo before treatment. Then handheld photoacoustic imaging system was used to determine the tumor location during the surgery and guided the photothermal therapy. The experiment result based on orthotopic tumor demonstrated that this synergistic method could effectively reduce tumor residual and satellite metastases by 85.71% compared with the routine photothermal method without handheld PAI guidance. These results indicate that this multimodality molecular imaging-guided photothermal therapy method is promising with a good prospect in clinical application.
WOS关键词IN-VIVO ; HEPATOCELLULAR-CARCINOMA ; CANCER ; TOMOGRAPHY ; SYSTEM
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000432965400001
资助机构National Key Research Program of China(2016YFA0100900 ; National Natural Science Foundation of China(81227901 ; Key Research Program of the Chinese Academy of Sciences(KGZD-EW-T03) ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences(YZ201457) ; Beijing Natural Science Foundation(7174314) ; 2016YFA0100902) ; 815270805 ; 61231004 ; 81471739 ; 81472594 ; 81770781)
源URL[http://ir.ia.ac.cn/handle/173211/21694]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
3.Shandong Univ, Sch Control Sci & Engn, Inst Biomed Engn, Jinan 250061, Shandong, Peoples R China
4.Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Xibo,Jin, Yushen,Wang, Yi,et al. Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd[J]. CONTRAST MEDIA & MOLECULAR IMAGING,2018(2018):9321862.
APA Ma, Xibo.,Jin, Yushen.,Wang, Yi.,Zhang, Shuai.,Peng, Dong.,...&Tian, Jie.(2018).Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd.CONTRAST MEDIA & MOLECULAR IMAGING(2018),9321862.
MLA Ma, Xibo,et al."Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd".CONTRAST MEDIA & MOLECULAR IMAGING .2018(2018):9321862.

入库方式： OAI收割

来源：自动化研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。