Cerasomal doxorubicin with long-term storage stability and controllable sustained release
文献类型：期刊论文
| 作者 | Jin Yushen ; Yue Xiuli; Wu Xiaoyi; Cao Zhong; Dai Zhifei
|
| 刊名 | Acta Biomaterialia
 |
| 出版日期 | 2012-05-30 |
| 期号 | 8页码:3372-3380 |
| 关键词 | Cerasome Doxorubicin Controlled Release Sustained Release Storage Stability |
| 英文摘要 | Liposomal nanohybrid cerasomes display a remarkable ability to maintain their size and retain encapsulated doxorubicin (DOX) over a period of 90 days under storage conditions in solution compared with liposomes and liposils. Cerasomes retained 92.1 ± 2.9% of the drug payload after 90 days storage, much more than liposomes (35.2 ± 2.5%) and liposils (53.2 ± 5.5%). Under physiologically relevant conditions cerasomes exhibit a low initial burst in the first 5 h and subsequent sustained release of DOX over the next 150 h. Moreover, the magnitude of the initial burst and the rate of sustained release of DOX from cerasomes can be modulated by incorporating dipalmitoylphosphatidylglycerol (DPPG) in the cerasome structure and altering the ratios of the cerasome-forming lipid and phospholipids. Consequently, a wide range of release profiles can be achieved by altering the vesicle composition. Finally, human ovarian cancer cells are effectively killed by DOX released from cerasomes. Together these results suggest that cerasomes may be a promising drug delivery system for the long-term storage and controllable sustained release of the anticancer drug DOX. 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.ia.ac.cn/handle/173211/21808]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 推荐引用方式 GB/T 7714 | Jin Yushen,Yue Xiuli,Wu Xiaoyi,et al. Cerasomal doxorubicin with long-term storage stability and controllable sustained release[J]. Acta Biomaterialia,2012(8):3372-3380. |
| APA | Jin Yushen,Yue Xiuli,Wu Xiaoyi,Cao Zhong,&Dai Zhifei.(2012).Cerasomal doxorubicin with long-term storage stability and controllable sustained release.Acta Biomaterialia(8),3372-3380. |
| MLA | Jin Yushen,et al."Cerasomal doxorubicin with long-term storage stability and controllable sustained release".Acta Biomaterialia .8(2012):3372-3380. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。