PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model
文献类型：期刊论文
| 作者 | Li, Yuan1,2; Du, Yang3 ; Sun, Ting1,2; Xue, Huadan1,2; Jin, Zhengyu1,2; Tian, Jie3
|
| 刊名 | BMC CANCER
 |
| 出版日期 | 2018-06-19 |
| 卷号 | 18 |
| 关键词 | Pd-1 Zoledronic Acid Breast Cancer Therapy Checkpoint Inhibitior |
| DOI | 10.1186/s12885-018-4412-8 |
| 文献子类 | Article |
| 英文摘要 | Background: Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody against T cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model. |
| WOS关键词 | CHECKPOINT INHIBITORS ; PHASE-3 TRIAL ; OPEN-LABEL ; METASTASES ; ANTIBODY ; THERAPY ; LIGAND ; SAFETY |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000435892200004 |
| 资助机构 | National Natural Science Foundation of China(81227901 ; Key Projects in the National Science & Technology Pillar Program(2012BAI23B06) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 81470083 ; 81527805 ; 61231004 ; 81171390) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/21820]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China 2.Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging CAS, 95 ZhongGuanCun East Rd, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuan,Du, Yang,Sun, Ting,et al. PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model[J]. BMC CANCER,2018,18. |
| APA | Li, Yuan,Du, Yang,Sun, Ting,Xue, Huadan,Jin, Zhengyu,&Tian, Jie.(2018).PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.BMC CANCER,18. |
| MLA | Li, Yuan,et al."PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model".BMC CANCER 18(2018). |
入库方式： OAI收割
来源：自动化研究所
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