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Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging

文献类型：期刊论文

作者Zhan, Yonghua1; Shi, Sixiang2; Ehlerding, Emily B.3; Graves, Stephen A.3; Goel, Shreya2; Engle, Jonathan W.3; Liang, Jimin1; Tian, Jie5; Cai, Weibo2,3,4
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2017-11-08
卷号9期号:44页码:38304-38312
关键词Manganese Oxide Nanoparticles Cancer Positron Emission Tomography (Pet) Magnetic Resonance Imaging (Mri) Cd105 (Endoglin)
DOI10.1021/acsami.7b12216
文献子类Article
英文摘要Manganese oxide nanoparticles (Mn3O4 NPs) have attracted a great deal of attention in the field of biomedical imaging because of their ability to create an enhanced imaging signal in MRI as novel potent T-1 contrast agents. In this study, we present tumor vasculature-targeted imaging in mice using Mn3O4 NPs through conjugation to the anti-CD105 antibody TRC105 and radionuclide copper-64 (Cu-64, t(1/2): 12.7 h). The Mn3O4 conjugated NPs, Cu-64-NOTAMn(3)O(4)@PEG-TRC105, exhibited sufficient stability in vitro and in vivo. Serial positron emission tomography (PET) and magnetic resonance imaging (MRI) studies evaluated the pharmacokinetics and demonstrated targeting of Cu-64-NOTA-Mn3O4@PEG-TRC105 to 4T(1) murine breast tumors in vivo, compared to Cu-64-NOTA-Mn3O4@PEG. The specificity of Cu-64-NOTA-Mn3O4@PEG-TRC105 for the vascular marker CD105 was confirmed through in vivo, in vitro, and ex vivo experiments. Since Mn3O4 conjugated NPs exhibited desirable properties for T1 enhanced imaging and low toxicity, the tumor-specific Mn3O4 conjugated NPs reported in this study may serve as promising multifunctional nanoplatforms for precise cancer imaging and diagnosis.
WOS关键词IN-VIVO ; LOW-TEMPERATURE ; DRUG-DELIVERY ; MN3O4 NANOPARTICLES ; MONOCLONAL-ANTIBODY ; MNO NANOPARTICLES ; ENDOGLIN ANTIBODY ; CONTRAST AGENTS ; MRI CONTRAST ; CANCER
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000415140800017
资助机构University of Wisconsin Madison ; National Institutes of Health(NIBIB/NCI 1R01CA169365 ; American Cancer Society(125246-RSG-13-099-01-CCE) ; National Natural Science Foundation of China(81227901 ; Natural Science Basic Research Plan in Shaanxi Province of China(2017JM8057) ; Fundamental Research Funds for the Central Universities(JB171204) ; 1R01CA205101 ; 11727813 ; 1R01EB021336 ; 81571725 ; T32GM008505 ; 81230033 ; T32CA009206 ; 31371006 ; P30CA014520) ; 61405149 ; 81660505 ; 81627807)
源URL[http://ir.ia.ac.cn/handle/173211/21920]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
2.Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA
3.Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
4.Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53705 USA
5.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zhan, Yonghua,Shi, Sixiang,Ehlerding, Emily B.,et al. Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(44):38304-38312.
APA Zhan, Yonghua.,Shi, Sixiang.,Ehlerding, Emily B..,Graves, Stephen A..,Goel, Shreya.,...&Cai, Weibo.(2017).Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,9(44),38304-38312.
MLA Zhan, Yonghua,et al."Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 9.44(2017):38304-38312.

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来源：自动化研究所

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