"All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration
文献类型:期刊论文
作者 | Yan, Hao1,2; Shang, Wenting3; Sun, Xiaodan1; Zhao, Lingyun1; Wang, Jingyun1; Xiong, Zhiyuan1; Yuan, Jie1; Zhang, Ranran1; Huang, Qianli1; Wang, Kun3 |
刊名 | ADVANCED FUNCTIONAL MATERIALS |
出版日期 | 2018-02-28 |
卷号 | 28期号:9 |
关键词 | Breast Cancer Hyperthermia Molecular Imaging Nanomedicine Nanotheranostics |
DOI | 10.1002/adfm.201705710 |
文献子类 | Article |
英文摘要 | Great efforts have been devoted so far to combine nano-magnetic hyperthermia and nano-photothermal therapy to achieve encouraging additive therapeutic performance in vitro and in vivo with limitation to direct intratumoral injection and no guidance of multimodality molecular imaging. In this study, a novel multifunctional theranostic nanoplatform (MNP@PES-Cy7/2-DG) consisting of magnetic nanoparticles (MNPs), poly(3,4-ethylenedioxythiophene): poly(4-styre-nesulfonate) (PES), Cyanine7 (Cy7), and 2-deoxyglucose (2-DG)-polyethylene glycol is developed. They are then applied to combined photo-magnetic hyperthermia therapy under intravenous administration that is simultaneously guided by trimodality molecular imaging. Remarkably, nanoparticles are found aggregated mainly in the cytoplasm of tumor cells in vitro and in vivo, and exhibit stealth-like behavior with a long second-phase blood circulation half-life of 20.38 +/- 4.18 h. Under the guidance of photoacoustic/near-infrared fluorescence/magnetic resonance trimodality imaging, tumors can be completely eliminated under intracellular photo-magnetic hyperthermia therapy with additive therapeutic effect due to precise hyperthermia. This study may promote a further exploration of such a platform for clinical applications. |
WOS关键词 | IRON-OXIDE NANOPARTICLES ; PHOTOTHERMAL THERAPY ; PROSTATE-CANCER ; POLYPYRROLE NANOPARTICLES ; COMBINATION THERAPY ; DRUG CARRIER ; THERMOTHERAPY ; FEASIBILITY ; NANOCOMPOSITES ; EFFICIENCY |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
WOS记录号 | WOS:000426154500018 |
资助机构 | National Key Research and Development Program of China(2016YFB0700802) ; Inter governmental cooperation in science and technology(2016YFE0125300) ; NSFC(81172182 ; National Natural Science Foundation of China(81227901) ; 81671829) |
源URL | [http://ir.ia.ac.cn/handle/173211/21953] |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
作者单位 | 1.Tsinghua Univ, State Key Lab New Ceram & Fine Proc, Sch Mat Sci & Engn, Beijing 100084, Peoples R China 2.Tsinghua Univ, Engn Lab Functionalized Carbon Mat, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore |
推荐引用方式 GB/T 7714 | Yan, Hao,Shang, Wenting,Sun, Xiaodan,et al. "All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(9). |
APA | Yan, Hao.,Shang, Wenting.,Sun, Xiaodan.,Zhao, Lingyun.,Wang, Jingyun.,...&Feng, Si-Shen.(2018)."All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration.ADVANCED FUNCTIONAL MATERIALS,28(9). |
MLA | Yan, Hao,et al.""All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration".ADVANCED FUNCTIONAL MATERIALS 28.9(2018). |
入库方式: OAI收割
来源:自动化研究所
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