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Advanced nanomaterials targeting hypoxia to enhance radiotherapy

文献类型：期刊论文

作者Jia Li; Wenting Shang; Yong Li; Sirui Fu; Jie Tian; Ligong Lu
刊名INTERNATIONAL JOURNAL OF NANOMEDICINE
出版日期2018
卷号13页码:5925-5936
ISSN号1178-2013
关键词radiotherapy hypoxia nanomaterials hypoxia inducible factor 1
DOI10.2147/IJN.S173914
通讯作者Tian, Jie(jie.tian@ia.ac.cn) ; Lu, Ligong(luligong1969@126.com)
英文摘要Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials - aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment - is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element-based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1-targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray-or near-infrared-responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes.
WOS关键词OVERCOME TUMOR HYPOXIA ; DRUG-DELIVERY SYSTEMS ; BREAST-CANCER CELLS ; GOLD NANOPARTICLES ; OXYGEN DELIVERY ; CLINICAL-APPLICATIONS ; RECTAL-CANCER ; IN-VIVO ; MULTIFUNCTIONAL NANOTHERANOSTICS ; POSTOPERATIVE CHEMORADIOTHERAPY
资助项目National Key Research and Development Program of China[2017YFA0205 200] ; National Natural Science Foundation of China[81571785] ; National Natural Science Foundation of China[81771957] ; National Natural Science Foundation of China[81502642] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81501540] ; Natural Science Foundation of Guangdong Province, China[2016A030311055] ; Natural Science Foundation of Guangdong Province, China[2016A030313770] ; Natural Science Foundation of Guangdong Province, China[2015A030310108] ; Chinese Academy of Sciences[GJJSTD20170004] ; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences[20180111]
WOS研究方向Science & Technology - Other Topics ; Pharmacology & Pharmacy
语种英语
出版者DOVE MEDICAL PRESS LTD
WOS记录号WOS:000446664200001
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Chinese Academy of Sciences ; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences
源URL[http://ir.ia.ac.cn/handle/173211/22028]  
专题自动化研究所_中国科学院分子影像重点实验室
作者单位1.Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China
2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China
3.Beijing Key Laboratory of Molecular Imaging, Beijing, China
推荐引用方式
GB/T 7714		 Jia Li,Wenting Shang,Yong Li,et al. Advanced nanomaterials targeting hypoxia to enhance radiotherapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:5925-5936.
APA Jia Li,Wenting Shang,Yong Li,Sirui Fu,Jie Tian,&Ligong Lu.(2018).Advanced nanomaterials targeting hypoxia to enhance radiotherapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,13,5925-5936.
MLA Jia Li,et al."Advanced nanomaterials targeting hypoxia to enhance radiotherapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):5925-5936.

入库方式： OAI收割

来源：自动化研究所

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