Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier
文献类型：期刊论文
| 作者 | Li, Zhiqiang1,2,3; Wang, Baikui2,3; Zhang, Zheng2,3 ; Wang, Bo1; Xu, Qiangqiang1; Mao, Wenjie1; Tian, Jie1,4; Yang, Kai2,3; Wang, Fu1
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| 刊名 | MOLECULAR THERAPY
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| 出版日期 | 2018-05-02 |
| 卷号 | 26期号:5页码:1385-1393 |
| DOI | 10.1016/j.ymthe.2018.02.019 |
| 文献子类 | Article |
| 英文摘要 | Development of biocompatible nanomaterials with multiple functionalities for combination of radiotherapy and chemotherapy has attracted tremendous attention in cancer treatment. Herein, poly(ethylene glycol) (PEG) modified polydopamine (PDA) nanoparticles were successfully developed as a favorable biocompatible nanoplatform for co-loading antitumor drugs and radionuclides to achieve imaging-guided combined radio-chemotherapy. It is demonstrated that PEGylated PDA nanoparticles can effectively load two different drugs including sanguinarine (SAN) and metformin (MET), as well as radionuclides I-131 in one system. The loaded SAN and MET could inhibit tumor growth via inducing cell apoptosis and relieving tumor hypoxia, while labeling PDA-PEG with I-131 enables in vivo radionuclide imaging and radioisotope therapy. As revealed by the therapeutic efficacy both in cell and animal levels, the multifunctional PDA nanoparticles (I-131-PDA-PEG-SAN-MET) can effectively repress the growth of cancer cells in a synergistic manner without significant toxic side effects, exhibiting superior treatment outcome than the respective monotherapy. Therefore, this study provides a promising polymer-based platform to realize imaging-guided radioisotope/chemotherapy combination cancer treatment in future clinical application. |
| WOS关键词 | CANCER ; NANOPARTICLES ; VERSATILE ; PLATFORM ; CHEMOTHERAPY ; RESISTANCE |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000431485300022 |
| 资助机构 | National Natural Science Foundation of China(81571721 ; Natural Science Basis Research Plan in Shaanxi Province of China(2016JM8016) ; 81772010 ; 81227901 ; 81471716) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/22039]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China 2.Soochow Univ, State Key Lab Radiat Med & Protect, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China 3.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhiqiang,Wang, Baikui,Zhang, Zheng,et al. Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier[J]. MOLECULAR THERAPY,2018,26(5):1385-1393. |
| APA | Li, Zhiqiang.,Wang, Baikui.,Zhang, Zheng.,Wang, Bo.,Xu, Qiangqiang.,...&Wang, Fu.(2018).Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier.MOLECULAR THERAPY,26(5),1385-1393. |
| MLA | Li, Zhiqiang,et al."Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier".MOLECULAR THERAPY 26.5(2018):1385-1393. |
入库方式： OAI收割
来源：自动化研究所
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