Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations
文献类型：期刊论文
| 作者 | Liu, Bing1,2 ; Zhang, Xiaolong1,2; Cui, Yue1,2; Qin, Wen4; Tao, Yan1,2; Li, Jin1,2; Yu, Chunshui4; Jiang, Tianzi1,2,3,5,6
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| 刊名 | SCHIZOPHRENIA BULLETIN
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| 出版日期 | 2017-05-01 |
| 卷号 | 43期号:3页码:673-680 |
| 关键词 | Schizophrenia Polygenic Risk Score Cortical Gyrification Inferior Parietal Lobule |
| DOI | 10.1093/schbul/sbw051 |
| 文献子类 | Article |
| 英文摘要 | Schizophrenia is highly heritable, whereas the effect of each genetic variant is very weak. Since clinical heterogeneity and complexity of schizophrenia is high, considerable effort has been made to relate genetic variants to underlying neurobiological aspects of schizophrenia (endophenotypes). Given the polygenic nature of schizophrenia, our goal was to form a measure of additive genetic risk and explore its relationship to cortical morphology. Utilizing the data from a recent genome-wide association study that included nearly 37 000 cases of schizophrenia, we computed a polygenic risk score (PGRS) for each subject in 2 independent and healthy general populations. We then investigated the effect of polygenic risk for schizophrenia on cortical gyrification calculated from 3.0T structural imaging data in the discovery dataset (N = 315) and replication dataset (N = 357). We found a consistent effect of the polygenic risk for schizophrenia on cortical gyrification in the inferior parietal lobules in 2 independent general-population samples. A higher PGRS was significantly associated with a lower local gyrification index in the bilateral inferior parietal lobles, where case-control differences have been reported in previous studies on schizophrenia. Our findings strongly support the effectiveness of both PGRSs and endophenotypes in establishing the genetic architecture of psychiatry. Our findings may provide some implications regarding individual differences in the genetic risk for schizophrenia to cortical morphology and brain development. |
| WOS关键词 | INFERIOR PARIETAL LOBULE ; GENOME-WIDE ASSOCIATION ; WORKING-MEMORY ; BIPOLAR DISORDER ; SURFACE ; FMRI ; CONNECTIVITY ; METAANALYSIS ; PERFORMANCE ; THICKNESS |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000398997900027 |
| 资助机构 | National Key Basic Research and Development Program (973)(2011CB707800) ; Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91232718 ; 91132301) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/12380]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Jiang, Tianzi |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Zhongguancun East Rd 95, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China 4.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Bing,Zhang, Xiaolong,Cui, Yue,et al. Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations[J]. SCHIZOPHRENIA BULLETIN,2017,43(3):673-680. |
| APA | Liu, Bing.,Zhang, Xiaolong.,Cui, Yue.,Qin, Wen.,Tao, Yan.,...&Jiang, Tianzi.(2017).Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations.SCHIZOPHRENIA BULLETIN,43(3),673-680. |
| MLA | Liu, Bing,et al."Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations".SCHIZOPHRENIA BULLETIN 43.3(2017):673-680. |
入库方式： OAI收割
来源：自动化研究所
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