Cortical thickness development of human primary visual cortex related to the age of blindness onset
文献类型：期刊论文
| 作者 | Li, Qiaojun1,2 ; Song, Ming1,2; Xu, Jiayuan3; Qin, Wen3; Yu, Chunshui3; Jiang, Tianzi1,2,4,5; Jiang Tianzi
|
| 刊名 | BRAIN IMAGING AND BEHAVIOR
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 11期号:4页码:1029-1036 |
| 关键词 | Primary Visual Cortex Cortical Thickness Blindness Age Of Blindness Onset Adolescence |
| DOI | 10.1007/s11682-016-9576-8 |
| 文献子类 | Article |
| 英文摘要 | Blindness primarily induces structural alteration in the primary visual cortex (V1). Some studies have found that the early blind subjects had a thicker V1 compared to sighted controls, whereas late blind subjects showed no significant differences in the V1. This implies that the age of blindness onset may exert significant effects on the development of cortical thickness of the V1. However, no previous research used a trajectory of the age of blindness onset-related changes to investigate these effects. Here we explored this issue by mapping the cortical thickness trajectory of the V1 against the age of blindness onset using data from 99 blind individuals whose age of blindness onset ranged from birth to 34 years. We found that the cortical thickness of the V1 could be fitted well with a quadratic curve in both the left (F = 11.59, P = 3 x 10(-5)) and right hemispheres (F = 6.54, P = 2 x 10(-3)). Specifically, the cortical thickness of the V1 thinned rapidly during childhood and adolescence and did not change significantly thereafter. This trend was not observed in the primary auditory cortex (A1), primary motor cortex (M1), or primary somatosensory cortex (S1). These results provide evidence that an onset of blindness before adulthood significantly affects the cortical thickness of the V1 and suggest a critical period for cortical development of the human V1. |
| WOS关键词 | HUMAN PREFRONTAL CORTEX ; ACTIVATION ; PERFORMANCE ; PLASTICITY ; AWARENESS ; SURFACE ; PERIOD |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000407840500011 |
| 资助机构 | National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; National Natural Science Foundation of China(91132301 ; 91432302 ; 81471380 ; 81101040) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/12496]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Jiang Tianzi |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 推荐引用方式 GB/T 7714 | Li, Qiaojun,Song, Ming,Xu, Jiayuan,et al. Cortical thickness development of human primary visual cortex related to the age of blindness onset[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):1029-1036. |
| APA | Li, Qiaojun.,Song, Ming.,Xu, Jiayuan.,Qin, Wen.,Yu, Chunshui.,...&Jiang Tianzi.(2017).Cortical thickness development of human primary visual cortex related to the age of blindness onset.BRAIN IMAGING AND BEHAVIOR,11(4),1029-1036. |
| MLA | Li, Qiaojun,et al."Cortical thickness development of human primary visual cortex related to the age of blindness onset".BRAIN IMAGING AND BEHAVIOR 11.4(2017):1029-1036. |
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来源：自动化研究所
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