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Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects

文献类型：期刊论文

作者Ma, Guangyang1,2,3,4; Yang, Dan1,2,5; Qin, Wen1,2; Liu, Yong6; Jiang, Tianzi6; Yu, Chunshui1,2; Yu Chunshui
刊名FRONTIERS IN NEUROSCIENCE
出版日期2017-01-10
卷号10期号:10页码:612
关键词Functional Connectivity Hippocampus Congenitally Blind Late Blind Resting State
DOI10.3389/fnins.2016.00612
文献子类Article
英文摘要The hippocampus has exhibited navigation-related changes in volume and activity after visual deprivation; however, the resting-state functional connectivity (rsFC) changes of the hippocampus in the blind remains unknown. In this study, we focused on sub-region-specific rsFC changes of the hippocampus and their association with the onset age of blindness. The rsFC patterns of the hippocampal sub-regions (head, body and tail) were compared among 20 congenitally blind (CB), 42 late blind (LB), and 50 sighted controls (SC). Compared with the SC, both the CB and the LB showed increased hippocampal rsFCs with the posterior cingulate cortex, angular gyrus, parieto-occpital sulcus, middle occipito-temporal conjunction, inferior temporal gyrus, orbital frontal cortex, and middle frontal gyrus. In the blind subjects, the hippocampal tail had more extensive rsFC changes than the anterior hippocampus (body and head). The CB and the LB had similar changes in hippocampal rsFC. These altered rsFCs of the hippocampal sub-regions were neither correlated with onset age in the LB nor the duration of blindness in CB or LB subjects. The increased coupling of the hippocampal intrinsic functional network may reflect enhanced loading of the hippocampal-related networks for non-visual memory processing. Furthermore, the similar changes of hippocampal rsFCs between the CB and the LB suggests an experience-dependent rather than a developmental-dependent plasticity of the hippocampal intrinsic functional network.
WOS关键词VISUAL-CORTEX ; ORBITOFRONTAL CORTEX ; SPATIAL REPRESENTATION ; AUDITORY LOCALIZATION ; DEVELOPMENTAL VISION ; OCCIPITAL CORTEX ; PARIETAL CORTEX ; PLACE CELLS ; LATE-ONSET ; CONNECTIVITY
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000391497800002
资助机构National Natural Science Foundation of China(81401394 ; 81425013 ; 91332113 ; 81270020 ; 81271551)
源URL[http://ir.ia.ac.cn/handle/173211/13200]  
专题自动化研究所_脑网络组研究中心
通讯作者Yu Chunshui
作者单位1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct imaging, Tianjin, Peoples R China
3.Tianjin Med Univ, Key Lab Hormones & Dev, Minist Hlth, Tianjin Key Lab Metab Dis,Tianjin Metab Dis Hosp, Tianjin, Peoples R China
4.Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin, Peoples R China
5.Tianjin Cent Hosp Gynecol Obstet, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Guangyang,Yang, Dan,Qin, Wen,et al. Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects[J]. FRONTIERS IN NEUROSCIENCE,2017,10(10):612.
APA Ma, Guangyang.,Yang, Dan.,Qin, Wen.,Liu, Yong.,Jiang, Tianzi.,...&Yu Chunshui.(2017).Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects.FRONTIERS IN NEUROSCIENCE,10(10),612.
MLA Ma, Guangyang,et al."Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects".FRONTIERS IN NEUROSCIENCE 10.10(2017):612.

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来源：自动化研究所

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