Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults
文献类型：期刊论文
| 作者 | Shen, Junlin1; Zhang, Peng1; Liu, Huaigui1; Xu, Lixue1; Xu, Jiayuan1; Qin, Wen1; Liu, Bing2 ; Jiang, Tianzi2; Yu, Chunshui1
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| 刊名 | BRAIN STRUCTURE & FUNCTION
 |
| 出版日期 | 2016-11-01 |
| 卷号 | 221期号:8页码:4103-4110 |
| 关键词 | Fmri Sorl1 Snps Linkage Disequilibrium Neuroimaging |
| DOI | 10.1007/s00429-015-1149-x |
| 文献子类 | Article |
| 英文摘要 | The sortilin-related receptor 1 (SORL1) gene has been associated with late-onset Alzheimer's disease (LOAD) and structural impairments in several ethnic populations. However, how this gene affects brain function properties remains unclear. We investigated associations of SORL1 rs2070045 with functional connectivity density (FCD) in healthy young adults. This single-nucleotide polymorphism was selected because it is the SORL1 variant that has been frequently associated with LOAD in several populations, including the Chinese Han population. A total of 275 healthy young Chinese Han subjects with successful genotyping and MRI examinations were included. The effect of SORL1 rs2070045 was explored using a voxel-wise FCD analysis. A significant effect of SORL1 rs2070045 on the FCD was found in the right inferior temporal gyrus. The risk G allele carriers of the rs2070045 exhibited a lower FCD than the protective TT carriers. This effect was independent of the status of apolipoprotein E. This study provides the first evidence that the SORL1 gene is associated with brain FCD differences in healthy young adults. In the genetic risk subjects, connectivity impairment already starts during young adulthood, which may predispose the risk allele carriers to be susceptible to LOAD after several decades. |
| WOS关键词 | ONSET ALZHEIMERS-DISEASE ; MILD COGNITIVE IMPAIRMENT ; HAN CHINESE POPULATION ; RS2070045 POLYMORPHISM ; JAPANESE POPULATION ; APOE GENOTYPE ; GENOME-WIDE ; HUMAN BRAIN ; ASSOCIATION ; RISK |
| WOS研究方向 | Anatomy & Morphology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000386352500016 |
| 资助机构 | National Natural Science Foundation of China(81425013 ; 81301202 ; 81301201 ; 91332113 ; 81271551) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/13334]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Junlin,Zhang, Peng,Liu, Huaigui,et al. Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults[J]. BRAIN STRUCTURE & FUNCTION,2016,221(8):4103-4110. |
| APA | Shen, Junlin.,Zhang, Peng.,Liu, Huaigui.,Xu, Lixue.,Xu, Jiayuan.,...&Yu, Chunshui.(2016).Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults.BRAIN STRUCTURE & FUNCTION,221(8),4103-4110. |
| MLA | Shen, Junlin,et al."Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults".BRAIN STRUCTURE & FUNCTION 221.8(2016):4103-4110. |
入库方式： OAI收割
来源：自动化研究所
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