Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET
文献类型：期刊论文
| 作者 | Liu, Shuai1,2; Wang, Yinyan3; Xu, Kaibin4,5 ; Ping, Fan2,6; Wang, Renzhi1,2; Li, Fang2,7; Cheng, Xin2,7
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| 刊名 | NEUROIMAGE-CLINICAL
 |
| 出版日期 | 2016 |
| 卷号 | 12页码:415-419 |
| 关键词 | Cushing's Disease Positron Emission Tomography Cortisol Voxel-based Analysis |
| DOI | 10.1016/j.nicl.2016.08.018 |
| 文献子类 | Article |
| 英文摘要 | Chronic exposure to elevated levels of glucocorticoids can exert a neurotoxic effect in patients, possibly manifesting as molecular imaging alterations in patients. The aim of this study was to investigate the potential association between brain metabolism and elevated hormone level using F-18-fluorodeoxyglucose positron emission tomography. We retrospectively enrolled 92 consecutive patients with confirmed diagnosis of Cushing's disease. A voxel-based analysis was performed to investigate the association between cerebral F-18-fluorodeoxyglucose uptake and serum cortisol level. Relatively impaired metabolism of specific brain regions correlated with serum-cortisol level was found. Specifically, notable correlations were found in the hippocampus, amygdala, and cerebellum, regions considered to be involved in the regulation and central action of glucocorticoids. Moreover, some hormone-associated regions were found in the frontal and occipital cortex, possibly mediating the cognitive changes seen in Cushing's disease. Our findings link patterns of perturbed brain metabolism relates to individual hormone level, thus presenting a substrate for cognitive disturbances seen in Cushing's disease patients, as well as in other conditions with abnormal cortisol levels. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. |
| WOS关键词 | PITUITARY-ADRENOCORTICAL AXIS ; ANTERIOR CINGULATE CORTEX ; HIPPOCAMPAL ATROPHY ; CORTISOL-LEVELS ; STRESS ; MEMORY ; VOLUME ; TRANSPORT ; NEURONS ; RAT |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000390196400048 |
| 资助机构 | National Natural Science Foundation of China(81201121) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/13362]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China 2.Peking Union Med Coll, Beijing 100730, Peoples R China 3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 6.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China 7.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shuai,Wang, Yinyan,Xu, Kaibin,et al. Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET[J]. NEUROIMAGE-CLINICAL,2016,12:415-419. |
| APA | Liu, Shuai.,Wang, Yinyan.,Xu, Kaibin.,Ping, Fan.,Wang, Renzhi.,...&Cheng, Xin.(2016).Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET.NEUROIMAGE-CLINICAL,12,415-419. |
| MLA | Liu, Shuai,et al."Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET".NEUROIMAGE-CLINICAL 12(2016):415-419. |
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来源：自动化研究所
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