Altered microstructure rather than morphology in the corpus callosum after lower limb amputation
文献类型：期刊论文
| 作者 | Li, Zhichao1; Li, Chuanming1; Fan, Lingzhong2 ; Jiang, Guangyao1; Wu, Jixiang3; Jiang, Tianzi2; Yin, Xuntao1; Wang, Jian1
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-03-17 |
| 卷号 | 7 |
| DOI | 10.1038/srep44780 |
| 文献子类 | Article |
| 英文摘要 | The corpus callosum (CC) has been implicated in the reorganization of the brain following amputation. However, it is unclear which regions of the CC are involved in this process. In this study, we explored the morphometric and microstructural changes in CC subregions in patients with unilateral lower limb amputation. Thirty-eight patients and 38 age-and gender-matched normal controls were included. The CC was divided into five regions, and the area, thickness and diffusion parameters of each region were investigated. While morphometric analysis showed no significant differences between the two groups, amputees showed significant higher values in axial diffusivity, radial diffusivity and mean diffusivity in region II of the CC, which connects the bilateral premotor and supplementary motor areas. In contrast, the mean fractional anisotropy value of the fibers generated by these cortical areas, as measured by tractography, was significantly smaller in amputees. These results demonstrate that the interhemispheric pathways contributing to motor coordination and imagery are reorganized in lower limb amputees. |
| WOS关键词 | PRIMARY MOTOR CORTEX ; WHITE-MATTER MICROSTRUCTURE ; PHANTOM LIMB ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; RADIAL DIFFUSIVITY ; BRAIN ACTIVATION ; PREMOTOR CORTEX ; SEX-DIFFERENCES ; PAIN |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000396834800001 |
| 资助机构 | National Natural Science Foundation of China for Young Scholars(81301205) ; Open Project Program of the National Laboratory of Pattern Recognition (NLPR) in China(201306283) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/14431]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing 400038, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Third Mil Med Univ, Southwest Hosp, Dept Rehabil, Chongqing 400038, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhichao,Li, Chuanming,Fan, Lingzhong,et al. Altered microstructure rather than morphology in the corpus callosum after lower limb amputation[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Li, Zhichao.,Li, Chuanming.,Fan, Lingzhong.,Jiang, Guangyao.,Wu, Jixiang.,...&Wang, Jian.(2017).Altered microstructure rather than morphology in the corpus callosum after lower limb amputation.SCIENTIFIC REPORTS,7. |
| MLA | Li, Zhichao,et al."Altered microstructure rather than morphology in the corpus callosum after lower limb amputation".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：自动化研究所
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