A computational approach towards the microscale mouse brain connectome from the mesoscale
文献类型：期刊论文
| 作者 | Zhang, Tielin1 ; Zeng, Yi1,2,3; Xu, Bo1,2,3
|
| 刊名 | JOURNAL OF INTEGRATIVE NEUROSCIENCE
 |
| 出版日期 | 2017 |
| 卷号 | 16期号:3页码:291-306 |
| 关键词 | Microscale Mouse Brain Connectome Brain Connectivity Atlas Motif Distribution Synaptic Degree Distribution Analysis |
| DOI | 10.3233/JIN-170019 |
| 文献子类 | Article |
| 英文摘要 | The wiring diagram of the mouse brain presents an indispensable foundation for the research on basic and applied neurobiology. It is also essential as a structural foundation for computational simulation of the brain. Different scales of the connectome give us different hints and clues to understand the functions of the nervous system and how they process information. However, compared to the macroscale and most recent mesoscale mouse brain connectome studies, there is no complete whole brain microscale connectome available because of the scalability and accuracy of automatic recognition techniques. Different scales of the connectivity data are comprehensive descriptions of the whole brain at different levels of details. Hence connectivity results from a neighborhood scale may help to predict each other. Here we report a computational approach to bring the mesoscale connectome a step forward towards the microscale from the perspective of neuron, synapse and network motifs distribution by the connectivity data at the mesoscale and some facts from the anatomical experiments at the microscale. These attempts make a step forward towards the efforts of microscale mouse brain connectome given the fact that the detailed microscale connectome results are still far to be produced due to the limitation of current nano-scale 3-D reconstruction techniques. The generated microscale mouse brain will play a key role on the understanding of the behavioral and cognitive processes of the mouse brain. In this paper, the conversion method which could get the approximate number of neurons and synapses in microscale is proposed and tested in sub-regions of Hippocampal Formation (HF), and is generalized to the whole brain. As a step forward towards understanding the microscale connectome, we propose a microscale motif prediction model to generate understanding on the microscale structure of different brain region from network motif perspective. Correlation analysis shows that the predicted motif distribution is very relevant to the real anatomical brain data at microscale. |
| WOS关键词 | NETWORK ; CORTEX ; NUMBER ; VOLUME |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000402301000004 |
| 资助机构 | Chinese Academy of Sciences(XDB02060007) ; Beijing Municipal Commission of Science and Technology(Z161100000216124) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/15122]  |
| 专题 | 类脑智能研究中心_类脑认知计算 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Tielin,Zeng, Yi,Xu, Bo. A computational approach towards the microscale mouse brain connectome from the mesoscale[J]. JOURNAL OF INTEGRATIVE NEUROSCIENCE,2017,16(3):291-306. |
| APA | Zhang, Tielin,Zeng, Yi,&Xu, Bo.(2017).A computational approach towards the microscale mouse brain connectome from the mesoscale.JOURNAL OF INTEGRATIVE NEUROSCIENCE,16(3),291-306. |
| MLA | Zhang, Tielin,et al."A computational approach towards the microscale mouse brain connectome from the mesoscale".JOURNAL OF INTEGRATIVE NEUROSCIENCE 16.3(2017):291-306. |
入库方式： OAI收割
来源：自动化研究所
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