中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 自动化研究所
  3. 中国科学院自动化研究所
  4. 脑图谱与类脑智能实验室
  5. 微观重建与智能分析
An automated pipeline for mitochondrial segmentation on ATUM-SEM stacks

文献类型：期刊论文

作者Li, Weifu1,2; Deng, Hao2,3; Rao, Qiang2; Xie, Qiwei2; Chen, Xi2; Han, Hua2,4,5
刊名JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
出版日期2017-06-01
卷号15期号:3页码:1750015
关键词Atum-sem Membrane Enhancement Mitochondria Group-similarity
DOI10.1142/S0219720017500159
文献子类Article
英文摘要It is possible now to look more closely into mitochondrial physical structures due to the rapid development of electron microscope (EM). Mitochondrial physical structures play important roles in both cellular physiology and neuronal functions. Unfortunately, the segmentation of mitochondria from EM images has proven to be a difficult and challenging task, due to the presence of various subcellular structures, as well as image distortions in the sophisticated background. Although the current state-of-the-art algorithms have achieved some promising results, they have demonstrated poor performances on these mitochondria which are in close proximity to vesicles or various membranes. In order to overcome these limitations, this study proposes explicitly modelling the mitochondrial double membrane structures, and acquiring the image edges by way of ridge detection rather than by image gradient. In addition, this study also utilizes group-similarity in context to further optimize the local misleading segmentation. Then, the experimental results determined from the images acquired by automated tape-collecting ultramicrotome scanning electron microscopy (ATUM-SEM) demonstrate the effectiveness of this study's proposed algorithm.
WOS关键词ELECTRON-MICROSCOPY ; IMAGE SEGMENTATION ; CANCER ; RECONSTRUCTION ; SHAPE
WOS研究方向Biochemistry & Molecular Biology ; Computer Science ; Mathematical & Computational Biology
语种英语
WOS记录号WOS:000404061500009
资助机构Special Program of Beijing Municipal Science & Technology Commission(Z161100000216146) ; Strategic Priority Research Program of the CAS(XDB02060001) ; National Science Foundation of China(61673381 ; Institute of Automation, CAS(Y3J2031DZ1) ; 61201050 ; 61306070)
源URL[http://ir.ia.ac.cn/handle/173211/15243]  
专题类脑智能研究中心_微观重建与智能分析
作者单位1.Hubei Univ, Fac Math & Stat, Wuhan 430062, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.Macau Univ Sci & Technol, Fac Informat Technol, Hefei 999078, Macau, Peoples R China
4.Univ Chinese Acad Sci, Future Technol Coll, Beijing 100190, Peoples R China
5.CBS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Li, Weifu,Deng, Hao,Rao, Qiang,et al. An automated pipeline for mitochondrial segmentation on ATUM-SEM stacks[J]. JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY,2017,15(3):1750015.
APA Li, Weifu,Deng, Hao,Rao, Qiang,Xie, Qiwei,Chen, Xi,&Han, Hua.(2017).An automated pipeline for mitochondrial segmentation on ATUM-SEM stacks.JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY,15(3),1750015.
MLA Li, Weifu,et al."An automated pipeline for mitochondrial segmentation on ATUM-SEM stacks".JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY 15.3(2017):1750015.

入库方式： OAI收割

来源：自动化研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。