Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens
文献类型：期刊论文
| 作者 | Xia, Xiaoluan1; Fan, Lingzhong2 ; Cheng, Chen1; Eickhoff, Simon B.4,5; Chen, Junjie1; Li, Haifang1; Jiang, Tianzi2,3,6,7
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| 刊名 | HUMAN BRAIN MAPPING
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| 出版日期 | 2017-08-01 |
| 卷号 | 38期号:8页码:3878-3898 |
| 关键词 | Nucleus Accumbens Connectivity-based Parcellation Tractography Functional Connectivity Meta-analytic Connectivity Modeling |
| DOI | 10.1002/hbm.23636 |
| 文献子类 | Review |
| 英文摘要 | The subdifferentiation of the nucleus accumbens (NAc) has been extensively studied using neuroanatomy and histochemistry, yielding a well-accepted dichotomic shell/core architecture that reflects dissociable roles, such as in reward and aversion, respectively. However, in vivo parcellation of these structures in humans has been rare, potentially impairing future research into the structural and functional characteristics and alterations of putative NAc subregions. Here, we used three complementary parcellation schemes based on tractography, task-independent functional connectivity, and task-dependent co-activation to investigate the regional differentiation within the NAc. We found that a 2-cluster solution with shell-like and core-like subdivisions provided the best description of the data and was consistent with the earlier anatomical shell/core architecture. The consensus clusters from this optimal solution, which was based on the three schemes, were used as the final parcels for the subsequent connection analyses. The resulting connectivity patterns presented inter-hemispheric symmetry, convergence and divergence across the modalities, and, most importantly, clearly distinct patterns between the two subregions. This convergent connectivity patterns also confirmed the connections in animal models, supporting views that the two subregions could have antagonistic roles in some circumstances. Finally, the identified parcels should be helpful in further neuroimaging studies of the NAc. Hum Brain Mapp 38:3878-3898, 2017. (c) 2017 Wiley Periodicals, Inc. |
| WOS关键词 | HUMAN CONNECTOME PROJECT ; ANTERIOR CINGULATE CORTEX ; INFERIOR PARIETAL LOBULE ; DEEP BRAIN-STIMULATION ; CONVERGENT FUNCTIONAL ARCHITECTURE ; INFRALIMBIC PREFRONTAL CORTEX ; VENTRAL TEGMENTAL AREA ; HUMAN FRONTAL POLE ; BASAL GANGLIA ; ORBITOFRONTAL CORTEX |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000404963900009 |
| 资助机构 | National Key Basic Research and Development Program (973)(2011CB707801 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91432302 ; Deutsche Forschungsgemeinschaft(EI 816/4-1 ; National Institute of Mental Health(R01-MH074457) ; Helmholtz Portfolio Theme "Supercomputing and Modeling for the Human Brain" ; European Union Seventh Framework Programme(604102) ; Beijing Municipal Science & Technology Commission(Z161100000216139) ; 2012CB720702) ; 91132301 ; EI 816/6-1) ; 81501179 ; 81270020 ; 61373101 ; 61472270 ; 61402318) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/15248]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030600, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Res Ctr Juelich, Inst Neurosci & Med INM 1, D-52425 Julich, Germany 5.Heinrich Heine Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, D-40225 Dusseldorf, Germany 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Xia, Xiaoluan,Fan, Lingzhong,Cheng, Chen,et al. Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens[J]. HUMAN BRAIN MAPPING,2017,38(8):3878-3898. |
| APA | Xia, Xiaoluan.,Fan, Lingzhong.,Cheng, Chen.,Eickhoff, Simon B..,Chen, Junjie.,...&Jiang, Tianzi.(2017).Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens.HUMAN BRAIN MAPPING,38(8),3878-3898. |
| MLA | Xia, Xiaoluan,et al."Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens".HUMAN BRAIN MAPPING 38.8(2017):3878-3898. |
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来源：自动化研究所
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