Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis
文献类型：期刊论文
| 作者 | Zhang, Yuanchao1; Fang, Tao1; Wang, Yue1; Guo, Xin1; Alarefi, Abdulqawi1; Wang, Jian2; Jiang, Tianzi1,3 ; Zhang, Jiuquan2
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| 刊名 | BRAIN IMAGING AND BEHAVIOR
 |
| 出版日期 | 2017-02-01 |
| 卷号 | 11期号:1页码:1-7 |
| 关键词 | Amyotrophic Lateral Sclerosis Cortical Folding Local Gyrification Index Functional Connectivity White Matter Connectivity |
| DOI | 10.1007/s11682-015-9499-9 |
| 文献子类 | Article |
| 英文摘要 | Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the present study, we applied a surface-based local gyrification index (LGI) from high resolution MRI data to quantify the cortical folding in matched samples of 25 ALS patients versus 25 healthy controls. Using resting-state fMRI data, we further conducted seed-based functional connectivity analysis to explore the functional correlate of the cortical folding changes. We found that ALS patients had significantly reduced LGI in right occipital cortex and that abnormality in this region associated with decreased functional connectivity in the bilateral precuneus. This set of findings was speculated to result from disturbed white matter connectivity in ALS. In the patient group, we revealed significant negative correlations between disease duration and the LGIs of a cluster in the left superior frontal gyrus, which may reflect the cognitive deterioration in ALS. In summary, our results suggest that LGI may provide a useful means to assess ALS-related neurodegeneration and to study the pathophysiology of ALS. |
| WOS关键词 | MILD COGNITIVE IMPAIRMENT ; WHITE-MATTER ; FDG-PET ; SURFACE-AREA ; ALS-FTD ; BRAIN ; THICKNESS ; WIDESPREAD ; DEFICITS ; CRITERIA |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000400575300001 |
| 资助机构 | National Basic Research Program of China (973 program)(2011CB707800) ; Natural Science Foundation of China(81101000) ; Plan A of Science and Technology Support Program from Science and Technology Department of Sichuan Province(2014SZ0014) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/15270]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 2.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing 400038, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yuanchao,Fang, Tao,Wang, Yue,et al. Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(1):1-7. |
| APA | Zhang, Yuanchao.,Fang, Tao.,Wang, Yue.,Guo, Xin.,Alarefi, Abdulqawi.,...&Zhang, Jiuquan.(2017).Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis.BRAIN IMAGING AND BEHAVIOR,11(1),1-7. |
| MLA | Zhang, Yuanchao,et al."Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis".BRAIN IMAGING AND BEHAVIOR 11.1(2017):1-7. |
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来源：自动化研究所
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