Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study
文献类型：期刊论文
| 作者 | Zhang, Yujin1,2 ; Yang, Yi3; Si, Juanning1,2; Xia, Xiaoyu3; He, Jianghong3; Jiang, Tianzi1,2,4,5,6
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| 刊名 | NEUROIMAGE-CLINICAL
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| 出版日期 | 2018 |
| 卷号 | 17期号:2018页码:1-9 |
| 关键词 | Disorders Of Consciousness Spinal Cord Stimulation Functional Near-infrared Spectroscopy Inter-stimulus Interval Prefrontal Cortex |
| DOI | 10.1016/j.nicl.2017.09.017 |
| 文献子类 | Article |
| 英文摘要 | Spinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize the protocol, previous studies evaluated the frequency-specific effects of SCS on neurophysiological activities. However, whether and how the inter-stimulus interval (ISI) parameter affects the SCS neuromodulation in DOC remains unknown. We enrolled nine DOC patients who had implanted SCS devices and conducted three different durations of ISIs. Using functional near-infrared spectroscopy (fNIRS), we monitored the blood volume fluctuations in the prefrontal and occipital cortices during the SCS. The results showed that short stimuli (30 s) induced significant cerebral blood volume changes, especially in the prefrontal cortex, an important area in the consciousness system. By comparing the mean value of the responses from the first and the last block in each session, a shorter ISI was found to improve the blood volume in the prefrontal cortex. This phenomenon was more significant for the subgroup of patients with a favorable prognosis. These preliminary results imply that the ISI may be an important factor for SCS. The research paradigm proposed here also provides insights for further quantitative evaluations of the therapeutic effects of neuromodulation. |
| WOS关键词 | PERSISTENT VEGETATIVE STATE ; BRAIN-INJURY ; THERAPEUTIC INTERVENTIONS ; CEREBRAL METABOLISM ; BLOOD-VOLUME ; CORTEX ; CONNECTIVITY ; MEMORY ; TIME ; COMA |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000426180300001 |
| 资助机构 | National Key Research and Development Program of China(2017YFB1002502) ; National Natural Science Foundation of China(31571003 ; National Natural Science Foundation of Beijing(7164302) ; 81501550 ; 81600919) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/15488]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.PLA Army Gen Hosp, Dept Neurosurg, Beijing 100700, Peoples R China 4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 625014, Sichuan, Peoples R China 5.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing 100190, Peoples R China 6.Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Zhang, Yujin,Yang, Yi,Si, Juanning,et al. Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study[J]. NEUROIMAGE-CLINICAL,2018,17(2018):1-9. |
| APA | Zhang, Yujin,Yang, Yi,Si, Juanning,Xia, Xiaoyu,He, Jianghong,&Jiang, Tianzi.(2018).Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study.NEUROIMAGE-CLINICAL,17(2018),1-9. |
| MLA | Zhang, Yujin,et al."Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study".NEUROIMAGE-CLINICAL 17.2018(2018):1-9. |
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来源：自动化研究所
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