he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects
文献类型：期刊论文
| 作者 | Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T. ; Zhang, X; Zhang, X; Zhang, X; Liu, B; Li, J; Zhang, X; Zhang, X; Zhang, X; Zhang, X
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| 刊名 | Scientific reports
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| 出版日期 | 2015-06 |
| 期号 | 5页码:10105 |
| 关键词 | Catechol-o-methyltransferase Functional Network Parahippocampal Cortex |
| 英文摘要 | The influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of COMT Val(158)Met genotypes on the connection patterns of the brain network and working memory (WM) in healthy, young Val/Val and Met carrier subjects. There were significant differences in the performance level on the 2-back WM task between the different COMT genotypes: Val/Val individuals exhibited a higher correct rate compared to the Met carriers. A two-sample t test was used to examine the differences in the eigenvector centrality maps, using age and gender as covariates of no interest, between the Val/Val and Met carriers. We found that the Val/Val individuals exhibited significantly higher eigenvector centrality compared to the Met carriers in the left parahippocampal cortex. Furthermore, a significantly positive correlation between the mean eigenvector centrality of the significant cluster and the correct rate of the 2-back WM task was observed. By using a voxel-wise data-driven method, our findings may provide plausible implications regarding individual differences in the genetic contribution of COMT Val158Met to the brain network and cognition. |
| 源URL | [http://ir.ia.ac.cn/handle/173211/20228]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 推荐引用方式 GB/T 7714 | Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.,Zhang, X,Zhang, X,et al. he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects[J]. Scientific reports,2015(5):10105. |
| APA | Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T..,Zhang, X.,Zhang, X.,Zhang, X.,Liu, B.,...&Zhang, X.(2015).he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects.Scientific reports(5),10105. |
| MLA | Zhang, X., Li, J., Qin, W., Yu, C., Liu, B., Jiang, T.,et al."he catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects".Scientific reports .5(2015):10105. |
入库方式： OAI收割
来源：自动化研究所
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