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Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis

文献类型：期刊论文

作者Du, Yuhui1,2; Fryer, Susanna L.3,4; Fu, Zening1; Lin, Dongdong1; Sui, Jing1,5,6; Chen, Jiayu1; Damaraju, Eswar1; Mennigen, Eva1,7; Stuart, Barbara3; Loewy, Rachel L.3
刊名NEUROIMAGE
出版日期2018-10-15
卷号180页码:632-645
关键词fMRI Dynamic functional connectivity Connectivity state ICA Schizophrenia Clinical high-risk
ISSN号1053-8119
DOI10.1016/j.neuroimage.2017.10.022
通讯作者Du, Yuhui(ydu@mrn.org)
英文摘要Individuals at clinical high-risk (CHR) for psychosis are characterized by attenuated psychotic symptoms. Only a minority of CHR individuals convert to full-blown psychosis. Therefore, there is a strong interest in identifying neurobiological abnormalities underlying the psychosis risk syndrome. Dynamic functional connectivity (DFC) captures time-varying connectivity over short time scales, and has the potential to reveal complex brain functional organization. Based on resting-state functional magnetic resonance imaging (fMRI) data from 70 healthy controls (HCs), 53 CHR individuals, and 58 early illness schizophrenia (ESZ) patients, we applied a novel group information guided ICA (GIG-ICA) to estimate inherent connectivity states from DFC, and then investigated group differences. We found that ESZ patients showed more aberrant connectivities and greater alterations than CHR individuals. Results also suggested that disease-related connectivity states occurred in CHR and ESZ groups. Regarding the dominant state with the highest contribution to dynamic connectivity, ESZ patients exhibited greater impairments than CHR individuals primarily in the cerebellum, frontal cortex, thalamus and temporal cortex, while CHR and ESZ populations shared common aberrances mainly in the supplementary motor area, parahippocampal gyrus and postcentral cortex. CHR-specific changes were also found in the connections between the superior frontal gyrus and calcarine cortex in the dominant state. Our findings suggest that CHR individuals generally show an intermediate functional connectivity pattern between HCs and SZ patients but also have unique connectivity alterations.
WOS关键词TIME-VARYING CONNECTIVITY ; GLOBAL SIGNAL REGRESSION ; RESTING-STATE NETWORKS ; GIG-ICA APPLICATION ; ULTRA-HIGH-RISK ; BRAIN CONNECTIVITY ; PRODROMAL SYMPTOMS ; WORKING-MEMORY ; MENTAL STATE ; FMRI
资助项目National Institutes of Health[5P20RR021938/P20GM103472] ; National Institutes of Health[R01EB020407] ; National Science Foundation[1539067] ; National Institute of Mental Health[R01MH076989] ; National Natural Science Foundation of China[61703253] ; Natural Science Foundation of Shanxi[2016021077]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000443271100025
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
资助机构National Institutes of Health ; National Science Foundation ; National Institute of Mental Health ; National Natural Science Foundation of China ; Natural Science Foundation of Shanxi
源URL[http://ir.ia.ac.cn/handle/173211/20272]  
专题自动化研究所_脑网络组研究中心
通讯作者Du, Yuhui
作者单位1.Mind Res Network, 1101 Yale Blvd NE, Albuquerque, NM 87131 USA
2.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China
3.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
4.San Francisco VA Healthcare Syst, Mental Hlth Serv, San Francisco, CA USA
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
7.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA
推荐引用方式
GB/T 7714		 Du, Yuhui,Fryer, Susanna L.,Fu, Zening,et al. Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis[J]. NEUROIMAGE,2018,180:632-645.
APA Du, Yuhui.,Fryer, Susanna L..,Fu, Zening.,Lin, Dongdong.,Sui, Jing.,...&Calhoun, Vince D..(2018).Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis.NEUROIMAGE,180,632-645.
MLA Du, Yuhui,et al."Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis".NEUROIMAGE 180(2018):632-645.

入库方式： OAI收割

来源：自动化研究所

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