Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults
文献类型：期刊论文
| 作者 | Xu, Jiayuan1,2; Qin, Wen1,2; Li, Qiaojun3 ; Li, Wei1,2; Liu, Feng1,2; Liu, Bing4,5; Jiang, Tianzi4,5; Yu, Chunshui1,2
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| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 27期号:11页码:5211-5221 |
| 关键词 | Catechol-o-methyltransferase Gender Gray Matter Volume Mediation Analysis Stroop Interference Resolution |
| DOI | 10.1093/cercor/bhw301 |
| 文献子类 | Article |
| 英文摘要 | There exist gender differences in the modulation of catechol-O-methyltransferase (COMT) Val158Met polymorphism on cognitive performance; however, the underlying gene-anatomy-cognition pathways remain unknown. Here we hypothesize that prefrontal volume may mediate the modulation of COMT Val158Met polymorphism on interference resolution capacity in a gender-dependent manner. In 261 healthy young human subjects (143 males and 118 females), a 2-way analysis of variance showed a COMT x gender interaction (P = 0.023) on interference resolution capacity. Val/Val subjects performed worse in Stroop interference test than Met/Met subjects only in males (P = 0.028). Voxel-wise analysis in the whole brain also exhibited a COMT x gender interaction on gray matter volume (GMV) in the left lateral frontal pole (FP). Val/Val male individuals exhibited significantly decreased GMV in the left lateral FP than Val/Met (P = 0.003) and Met/Met (P = 0.006) male carriers. Mediation analysis revealed that the GMV of the left lateral FP mediated the association between COMT polymorphism and interference resolution in males. These findings provide a gene-anatomy-cognition pathway to describe how COMT Val158Met polymorphism affects interference resolution capacity via modulating the prefrontal GMV in healthy male subjects. |
| WOS关键词 | ANTERIOR CINGULATE CORTEX ; METHYLTRANSFERASE VAL158MET GENOTYPE ; VAL(108/158) MET GENOTYPE ; GRAY-MATTER VOLUME ; COGNITIVE CONTROL ; STROOP TASK ; VAL(158)MET POLYMORPHISM ; SEX-DIFFERENCES ; FRONTAL-CORTEX ; DOWN-REGULATION |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000413209200013 |
| 资助机构 | Natural Science Foundation of China(81501451 ; 81425013 ; 81271551 ; 91132301 ; 81301201 ; 81301202) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/20326]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, 154 Anshan Rd, Tianjin 300052, Peoples R China 3.Tianjin Univ Commerce, Coll Informat Engn, Tianjin 300052, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jiayuan,Qin, Wen,Li, Qiaojun,et al. Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults[J]. CEREBRAL CORTEX,2017,27(11):5211-5221. |
| APA | Xu, Jiayuan.,Qin, Wen.,Li, Qiaojun.,Li, Wei.,Liu, Feng.,...&Yu, Chunshui.(2017).Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults.CEREBRAL CORTEX,27(11),5211-5221. |
| MLA | Xu, Jiayuan,et al."Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults".CEREBRAL CORTEX 27.11(2017):5211-5221. |
入库方式： OAI收割
来源：自动化研究所
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