Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging
文献类型：期刊论文
| 作者 | Liu, Shuai1,2; Wang, Yinyan1; Xu, Kaibin3 ; Wang, Zheng1,2; Fan, Xing2; Zhang, Chuanbao1,2; Li, Shaowu2,4; Qiu, Xiaoguang5; Jiang, Tao1,2,6
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| 刊名 | SCIENTIFIC REPORTS
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| 出版日期 | 2017-08-16 |
| 卷号 | 7 |
| DOI | 10.1038/s41598-017-08862-6 |
| 文献子类 | Article |
| 英文摘要 | Necrosis is a hallmark feature of glioblastoma (GBM). This study investigated the prognostic role of necrotic patterns in GBM using fractal dimension (FD) and lacunarity analyses of magnetic resonance imaging (MRI) data and evaluated the role of lacunarity in the biological processes leading to necrosis. We retrospectively reviewed clinical and MRI data of 95 patients with GBM. FD and lacunarity of the necrosis on MRI were calculated by fractal analysis and subjected to survival analysis. We also performed gene ontology analysis in 32 patients with available RNA-seq data. Univariate analysis revealed that FD < 1.56 and lacunarity > 0.46 significantly correlated with poor progression-free survival (p = 0.006 and p = 0.012, respectively) and overall survival (p = 0.008 and p = 0.005, respectively). Multivariate analysis revealed that both parameters were independent factors for unfavorable progression-free survival (p = 0.001 and p = 0.015, respectively) and overall survival (p = 0.002 and p = 0.007, respectively). Gene ontology analysis revealed that genes positively correlated with lacunarity were involved in the suppression of apoptosis and necrosis-associated biological processes. We demonstrate that the fractal parameters of necrosis in GBM can predict patient survival and are associated with the biological processes of tumor necrosis. |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; CELL-DEATH ; MULTIFORME ; ACTIVATION ; COMPLEXITY ; APOPTOSIS ; GLIOMAS ; CANCER |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000407674800001 |
| 资助机构 | Capital Medical Development Research Fund(2016-2-1073) ; National Key Research and Development Plan(2016YFC0902500) ; National Natural Science Foundation of China(81502495) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/20706]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China 2.Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.Capital Med Univ, Beijing Tiantan Hosp, Dept Neuroradiol, Beijing, Peoples R China 5.Capital Med Univ, Beijing Tiantan Hosp, Dept Radiat Oncol, Beijing, Peoples R China 6.Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shuai,Wang, Yinyan,Xu, Kaibin,et al. Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Liu, Shuai.,Wang, Yinyan.,Xu, Kaibin.,Wang, Zheng.,Fan, Xing.,...&Jiang, Tao.(2017).Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging.SCIENTIFIC REPORTS,7. |
| MLA | Liu, Shuai,et al."Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：自动化研究所
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