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Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders

文献类型：期刊论文

作者Xiao, Xiao1; Wang, Lu1; Wang, Chuang2; Yuan, Ti-Fei3; Zhou, Dongsheng4; Zheng, Fanfan5; Li, Lingyi1; Grigoroiu-Serbanescu, Maria6; Ikeda, Masashi7; Iwata, Nakao7
刊名TRANSLATIONAL PSYCHIATRY
出版日期2017-12-11
卷号7
DOI10.1038/s41398-017-0019-0
文献子类Article
英文摘要Bipolar disorder (BPD) and major depressive disorder (MDD) are primary major mood disorders. Recent studies suggest that they share certain psychopathological features and common risk genes, but unraveling the full genetic architecture underlying the risk of major mood disorders remains an important scientific task. The public genome-wide association study (GWAS) data sets offer the opportunity to examine this topic by utilizing large amounts of combined genetic data, which should ultimately allow a better understanding of the onset and development of these illnesses. Genome-wide meta-analysis was performed by combining two GWAS data sets on BPD and MDD (19,637 cases and 18,083 controls), followed by replication analyses for the loci of interest in independent 12,364 cases and 76,633 controls from additional samples that were not included in the two GWAS data sets. The single-nucleotide polymorphism (SNP) rs10791889 at 11q13.2 was significant in both discovery and replication samples. When combining all samples, this SNP and multiple other SNPs at 2q11.2 (rs717454), 8q21.3 (rs10103191), and 11q13.2 (rs2167457) exhibited genome-wide significant association with major mood disorders. The SNPs in 2q11.2 and 8q21.3 were novel risk SNPs that were not previously reported, and SNPs at 11q13.2 were in high LD with potential BPD risk SNPs implicated in a previous GWAS. The genome-wide significant loci at 2q11.2 and 11q13.2 exhibited strong effects on the mRNA expression of certain nearby genes in cerebellum. In conclusion, we have identified several novel loci associated with major mood disorders, adding further support for shared genetic risk between BPD and MDD. Our study highlights the necessity and importance of mining public data sets to explore risk genes for complex diseases such as mood disorders.
WOS关键词GENOME-WIDE ASSOCIATION ; BIPOLAR DISORDER ; DEPRESSIVE DISORDER ; GENE-EXPRESSION ; HIPPOCAMPAL STRUCTURE ; EUROPEAN POPULATIONS ; ALLELIC DIFFERENCES ; CONFERS RISK ; HAN CHINESE ; SUSCEPTIBILITY
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000419040900001
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13000000) ; CAS Pioneer Hundred Talents Program ; German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the the e:Med Programme(01ZX1314A ; German Research Foundation (DFG)(FOR2107 ; UEFISCDI, Bucharest, Romania(89/2012) ; German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent(01ZX1314A) ; Australian National Health ; Medical Research Council(GNT1037196) ; European Commission FP6 STRP grant(018947 (LSHG-CT-2006-01947)) ; European Community's Seventh Framework Programme (FP7) by the European Commission under the programme "Quality of Life and Management of the Living Resources" of 5th Framework Programme(HEALTH-F4-2007-201413 ; Netherlands Organization for Scientific Research ; Russian Foundation for Basic Research(NWO-RFBR 047.017.043) ; ZonMw grant(91111025) ; Hersenstichting Nederland(F2013(1)-28) ; 01ZX1314G) ; 11-1 ; QLG2-CT-2002-01254) ; NO246/10-1)
源URL[http://ir.ia.ac.cn/handle/173211/20757]  
专题自动化研究所_脑网络组研究中心
作者单位1.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China
2.Ningbo Univ, Sch Med, Prov Key Lab Pathophysiol, Dept Pharmacol, Ningbo, Zhejiang, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
4.Ningbo Kangning Hosp, Ningbo, Zhejiang, Peoples R China
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Alexandru Obregia Clin Psychiat Hosp, Biometr Psychiat Genet Res Unit, Bucharest, Romania
7.Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi, Japan
8.RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan
9.Natl Cerebral & Cardiovasc Ctr, Omics Res Ctr, Lab Omics Informat, Osaka, Japan
10.RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
推荐引用方式
GB/T 7714		 Xiao, Xiao,Wang, Lu,Wang, Chuang,et al. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders[J]. TRANSLATIONAL PSYCHIATRY,2017,7.
APA Xiao, Xiao.,Wang, Lu.,Wang, Chuang.,Yuan, Ti-Fei.,Zhou, Dongsheng.,...&MooDS Bipolar Consortium.(2017).Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.TRANSLATIONAL PSYCHIATRY,7.
MLA Xiao, Xiao,et al."Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders".TRANSLATIONAL PSYCHIATRY 7(2017).

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来源：自动化研究所

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