Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia
文献类型：期刊论文
| 作者 | Lin, Dongdong1,2; Chen, Jiayu1,2; Ehrlich, Stefan3; Bustillo, Juan R.4,5; Perrone-Bizzozero, Nora4,5; Walton, Esther6; Clark, Vincent P.1,2,7; Wang, Yu-Ping8; Sui, Jing1,2,9,10 ; Du, Yuhui1,2,11
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| 刊名 | SCHIZOPHRENIA BULLETIN
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| 出版日期 | 2018-03-01 |
| 卷号 | 44期号:2页码:443-452 |
| 关键词 | Brain Gray Matter Cross-tissue Dna Methylation Genetics Meqtl Schizophrenia |
| DOI | 10.1093/schbul/sbx068 |
| 文献子类 | Article |
| 英文摘要 | Closely linking genetics and environment factors, epigenetics has been of increasing interest in psychiatric disease studies. In this work, we integrated single nucleotide polymorphisms (SNPs), DNA methylation of blood and saliva, and brain gray matter (GM) measures to explore the role of genetic and epigenetic variation to the brain structure changes in schizophrenia (SZ). By focusing on the reported SZ genetic risk regions, we applied a multi-stage multivariate analysis to a discovery dataset (92 SZ patients and 110 controls, blood) and an independent replication dataset (93 SZ patients and 99 controls, saliva). Two pairs of SNP-methylation components were significantly correlated (r = .48 and .35) in blood DNA, and replicated (r = .46 and .29) in saliva DNA, reflecting cross-tissue SNP cis-effects. In the discovery data, both SNP-related methylation components were also associated with one GM component primarily located in cerebellum, caudate, and thalamus. Additionally, another methylation component in NOSIP gene with significant SZ patient differences (P = .009), was associated with 8 GM components (7 with patient differences) including superior, middle, and inferior frontal gyri, superior, middle, and inferior temporal gyri, cerebellum, insula, cuneus, and lingual gyrus. Of these, 5 methylation-GM associations were replicated (P < .05). In contrast, no pairwise significant associations were observed between SNP and GM components. This study strongly supports that compared to genetic variation, epigenetics show broader and more significant associations with brain structure as well as diagnosis, which can be cross-tissue, and the potential in explaining the mechanism of genetic risks in SZ. |
| WOS关键词 | NITRIC-OXIDE SYNTHASE ; INDEPENDENT COMPONENT ANALYSIS ; DNA METHYLATION ; INTERMEDIATE PHENOTYPES ; WIDE ASSOCIATION ; CORTEX ; RISK ; DISORDERS ; DISEASE ; BLOOD |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000427534200026 |
| 资助机构 | National Institutes of Health(P20GM103472 ; National Science Foundation(1539067) ; R01EB005846) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/20800]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Mind Res Network, Albuquerque, NM 87106 USA 2.Lovelace Biomed & Environm Res Inst, Albuquerque, NM 87106 USA 3.Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dresden, Germany 4.Univ New Mexico, Dept Neurosci, Albuquerque, NM 87131 USA 5.Univ New Mexico, Dept Psychiat, Albuquerque, NM USA 6.Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA 7.Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA 8.Tulane Univ, Dept Biomed Engn, New Orleans, LA 70118 USA 9.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 10.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Dongdong,Chen, Jiayu,Ehrlich, Stefan,et al. Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia[J]. SCHIZOPHRENIA BULLETIN,2018,44(2):443-452. |
| APA | Lin, Dongdong.,Chen, Jiayu.,Ehrlich, Stefan.,Bustillo, Juan R..,Perrone-Bizzozero, Nora.,...&Liu, Jingyu.(2018).Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia.SCHIZOPHRENIA BULLETIN,44(2),443-452. |
| MLA | Lin, Dongdong,et al."Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia".SCHIZOPHRENIA BULLETIN 44.2(2018):443-452. |
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来源：自动化研究所
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