No differences in brain microstructure between young KIBRA-C carriers and non-carriers
文献类型：期刊论文
| 作者 | Hu, Li1; Xu, Qunxing2; Li, Jizhen3; Wang, Feifei1; Xu, Xinghua1; Sun, Zhiyuan1; Ma, Xiangxing1; Liu, Yong4 ; Wang, Qing1; Wang, Dawei1
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| 刊名 | ONCOTARGET
 |
| 出版日期 | 2018-01-02 |
| 卷号 | 9期号:1页码:1200-1209 |
| 关键词 | Dki Kibra Brain Microstructure Young |
| DOI | 10.18632/oncotarget.23348 |
| 文献子类 | Article |
| 英文摘要 | KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers. No differences were detected between the TT homozygotes and C-allele carriers for any diffusion and kurtosis parameter. These results indicate KIBRA rs17070145 polymorphism likely has little or no effect on brain microstructure in young adults. |
| WOS关键词 | MILD COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE ; DIFFUSION KURTOSIS ; EPISODIC MEMORY ; APOE EPSILON-4 ; HEALTHY ADOLESCENTS ; GENE VARIANTS ; POLYMORPHISM ; ASSOCIATION ; PERFORMANCE |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000419615500097 |
| 资助机构 | National Natural Science Foundation of China(81400890 ; Shandong Provincial Key Research and Development Program(2017GSF218093 ; Shandong Provincial Science and Technology Major Project(2015ZDXX0801A01) ; Fundamental Research Funds of Shandong University(2017JC013) ; 81571062) ; 2017CXGC1502 ; 2017CXGC1504) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/21936]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Shandong Univ, Qilu Hosp, Dept Radiol, Jinan 250012, Shandong, Peoples R China 2.Shandong Univ, Qilu Hosp, Med Examinat Ctr, Jinan 250012, Shandong, Peoples R China 3.Mental Hlth Ctr Shandong Prov, Jinan 250012, Shandong, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Li,Xu, Qunxing,Li, Jizhen,et al. No differences in brain microstructure between young KIBRA-C carriers and non-carriers[J]. ONCOTARGET,2018,9(1):1200-1209. |
| APA | Hu, Li.,Xu, Qunxing.,Li, Jizhen.,Wang, Feifei.,Xu, Xinghua.,...&Wang, Dawei.(2018).No differences in brain microstructure between young KIBRA-C carriers and non-carriers.ONCOTARGET,9(1),1200-1209. |
| MLA | Hu, Li,et al."No differences in brain microstructure between young KIBRA-C carriers and non-carriers".ONCOTARGET 9.1(2018):1200-1209. |
入库方式： OAI收割
来源：自动化研究所
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