Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex
文献类型：期刊论文
| 作者 | Wang, Zhengchun1,2,3; Yu, Shan4,5,6 ; Fu, Yu7; Tzvetanov, Tzvetomir1,2,8; Zhou, Yifeng1,2,9
|
| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
 |
| 出版日期 | 2018-02-05 |
| 卷号 | 10 |
| 关键词 | Behavioral Measure Computational Modeling Neurophysiology Early Visual Processing Senescence |
| DOI | 10.3389/fnagi.2018.00014 |
| 文献子类 | Article |
| 英文摘要 | Aging-related declines in vision can decrease well-being of the elderly. Concerning early sensory changes as in the primary visual cortex, physiological and behavioral reports seem contradictory. Neurophysiological studies on orientation tuning properties suggested that neuronal changes might come from decreased cortical local inhibition. However, behavioral results either showed no clear deficits in orientation processing in older adults, or proposed stronger surround suppression. Through psychophysical experiments and computational modeling, we resolved these discrepancies by suggesting that lateral inhibition increased in older adults while neuronal orientation tuning widths, related to local inhibition, stayed globally intact across age. We confirmed this later result by re-analyzing published neurophysiological data, which showed no systematic tuning width changes, but instead displayed a higher neuronal noise with aging. These results suggest a stronger lateral inhibition and mixed effects on local inhibition during aging, revealing a more complex picture of age-related effects in the central visual system than people previously thought. |
| WOS关键词 | SENESCENT RHESUS-MONKEYS ; MIDDLE TEMPORAL AREA ; CORTICAL-CELLS ; FUNCTIONAL DEGRADATION ; CONTEXTUAL INTERACTIONS ; SPATIAL-DISTRIBUTION ; TILT ILLUSIONS ; OLDER-ADULTS ; AGED RATS ; SELECTIVITY |
| WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000424118500001 |
| 资助机构 | National Natural Science Foundation of China(31230032) ; China Postdoctoral Science Foundation(2015M571940) ; Fundamental Research Funds for the Central Universities ; Hundred-Talent Program of the Chinese Academy of Sciences ; K. C. Wong Magna Fund in Ningbo University |
| 源URL | [http://ir.ia.ac.cn/handle/173211/21945]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China 3.Ningbo Univ, Med Sch, Dept Physiol & Pharmacol, Ningbo, Zhejiang, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 6.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China 7.Kunming Univ Sci & Technol, Med Sch, Dept Basic Med, Kunming, Yunnan, Peoples R China 8.Hefei Univ Technol, Sch Comp & Informat, Hefei, Anhui, Peoples R China 9.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhengchun,Yu, Shan,Fu, Yu,et al. Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10. |
| APA | Wang, Zhengchun,Yu, Shan,Fu, Yu,Tzvetanov, Tzvetomir,&Zhou, Yifeng.(2018).Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex.FRONTIERS IN AGING NEUROSCIENCE,10. |
| MLA | Wang, Zhengchun,et al."Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex".FRONTIERS IN AGING NEUROSCIENCE 10(2018). |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。