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Variability in Resting State Network and Functional Network Connectivity Associated With Schizophrenia Genetic Risk: A Pilot Study

文献类型：期刊论文

作者Chen, Jiayu1; Rashid, Barnaly1,2; Yu, Qingbao1; Liu, Jingyu1,3; Lin, Dongdong1; Du, Yuhui1,4; Sui, Jing1,5,6; Calhoun, Vince D.1,3,7,8
刊名FRONTIERS IN NEUROSCIENCE
出版日期2018-03-01
卷号12
关键词Variability Resting State Network Functional Network Connectivity Schizophrenia Pgc Parallel Ica
DOI10.3389/fnins.2018.00114
文献子类Article
英文摘要Imaging genetics posits a valuable strategy for elucidating genetic influences on brain abnormalities in psychiatric disorders. However, association analysis between 2D genetic data (subject x genetic variable) and 3D first-level functional magnetic resonance imaging (fMRI) data (subject x voxel x time) has been challenging given the asymmetry in data dimension. A summary feature needs to be derived for the imaging modality to compute inter-modality association at subject level. In this work, we propose to use variability in resting state networks (RSNs) and functional network connectivity (FNC) as potential features for purpose of association analysis. We conducted a pilot study to investigate the proposed features in a dataset of 171 healthy controls and 134 patients with schizophrenia (SZ). We computed variability in RSN and FNC in a group independent component analysis framework and tested three types of variability metrics, namely Euclidean distance, Pearson correlation and Kullback-Leibler (KL) divergence. Euclidean distance and Pearson correlation metrics more effectively discriminated controls from patients than KL divergence. The group differences observed with variability in RSN and FNC were highly consistent, indicating patients presenting increased deviation from the cohort-common pattern of RSN and FNC than controls. The variability in RSN and FNC showed significant associations with network global efficiency, the more the deviation, the lower the efficiency. Furthermore, the RSN and FNC variability were found to associate with individual SZ risk SNPs as well as cumulative polygenic risk score for SZ. Collectively the current findings provide preliminary evidence for variability in RSN and FNC being promising imaging features that may find applications as biomarkers and in imaging genetic association analysis.
WOS关键词INDEPENDENT COMPONENT ANALYSIS ; GENOME-WIDE ASSOCIATION ; BIPOLAR DISORDER ; AUDITORY HALLUCINATIONS ; SYNAPTIC PLASTICITY ; BRAIN CONNECTIVITY ; HEALTHY CONTROLS ; NEUROANATOMY ; ACTIVATION ; FMRI
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000426390800001
资助机构National Institutes of Health(P20GM103472 ; National Science Foundation(1539067) ; National Natural Science Foundation of China(61703253 ; Natural Science Foundation of Shanxi(2016021077) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02060005) ; 1R01 EB006841 ; 81471367 ; R01MH106655) ; 61773380)
源URL[http://ir.ia.ac.cn/handle/173211/21967]  
专题自动化研究所_脑网络组研究中心
作者单位1.Mind Res Network, Albuquerque, NM 87106 USA
2.Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA
3.Univ New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA
4.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
7.Univ New Mexico, Sch Med, Dept Neurosci, Albuquerque, NM 87131 USA
8.Univ New Mexico, Sch Med, Dept Psychiat, Albuquerque, NM 87131 USA
推荐引用方式
GB/T 7714		 Chen, Jiayu,Rashid, Barnaly,Yu, Qingbao,et al. Variability in Resting State Network and Functional Network Connectivity Associated With Schizophrenia Genetic Risk: A Pilot Study[J]. FRONTIERS IN NEUROSCIENCE,2018,12.
APA Chen, Jiayu.,Rashid, Barnaly.,Yu, Qingbao.,Liu, Jingyu.,Lin, Dongdong.,...&Calhoun, Vince D..(2018).Variability in Resting State Network and Functional Network Connectivity Associated With Schizophrenia Genetic Risk: A Pilot Study.FRONTIERS IN NEUROSCIENCE,12.
MLA Chen, Jiayu,et al."Variability in Resting State Network and Functional Network Connectivity Associated With Schizophrenia Genetic Risk: A Pilot Study".FRONTIERS IN NEUROSCIENCE 12(2018).

入库方式： OAI收割

来源：自动化研究所

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