Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory
文献类型：期刊论文
| 作者 | Wang, Chao1,2 ; Liu, Bing3,4; Zhang, Xiaolong3,4; Cui, Yue3,4; Yu, Chunshui6; Jiang, Tianzi2,3,4,5,7
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2018-03-29 |
| 卷号 | 8 |
| DOI | 10.1038/s41598-018-23191-y |
| 文献子类 | Article |
| 英文摘要 | Dopamine is critical in pathophysiology and therapy of schizophrenia. Many studies have reported altered dopaminergic activity in the dorsal but not ventral striatum in schizophrenia. Based on the largest genome-wide association study of schizophrenia to date, we calculated the polygenic risk score (PGRS) of each subject in a healthy general group, including all variations in the set of functionally related genes involved in dopamine neurotransmitter system. We aimed to test whether the genetic variations in the dopaminergic pathway that have been identified as associated with schizophrenia are related to the function of the striatum and to working memory. We found that a higher PGRS was significantly associated with impairment in working memory. Moreover, resting-state functional connectivity analysis revealed that as the polygenic risk score increased, the connections between left putamen and caudate and the default mode network grew stronger, while the connections with the fronto-parietal network grew weaker. Our findings may shed light on the biological mechanism underlying the "dopamine hypothesis" of schizophrenia and provide some implications regarding the polygenic effects on the dopaminergic activity in the risk for schizophrenia. |
| WOS关键词 | DORSOLATERAL PREFRONTAL CORTEX ; GENOME-WIDE ASSOCIATION ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; RISK LOCI ; SCHIZOPHRENIA ; RECEPTORS ; STATE ; ABNORMALITIES ; INEFFICIENCY |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000428618900015 |
| 资助机构 | National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(31600920 ; Beijing Nova Program(2010B06) ; Natural Science Foundation of SZU(2016071) ; 91232718 ; 91132301) |
| 源URL | [http://ir.ia.ac.cn/handle/173211/22013]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Shenzhen Univ, Coll Psychol & Sociol, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Peoples R China 2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Sichuan, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci, Beijing, Peoples R China 6.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 推荐引用方式 GB/T 7714 | Wang, Chao,Liu, Bing,Zhang, Xiaolong,et al. Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory[J]. SCIENTIFIC REPORTS,2018,8. |
| APA | Wang, Chao,Liu, Bing,Zhang, Xiaolong,Cui, Yue,Yu, Chunshui,&Jiang, Tianzi.(2018).Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory.SCIENTIFIC REPORTS,8. |
| MLA | Wang, Chao,et al."Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory".SCIENTIFIC REPORTS 8(2018). |
入库方式： OAI收割
来源：自动化研究所
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