Seasonal regulations of energetics, serum concentrations of leptin, and uncoupling protein 1 content of brown adipose tissue in root voles (Microtus oeconomus) from the Qinghai-Tibetan plateau
文献类型：期刊论文
| 作者 | Wang, Jian-Mei; Zhang, Yan-Ming; Wang, De-Hua |
| 刊名 | journal of comparative physiology b-biochemical systemic and environmental physiology
 |
| 出版日期 | 2006-09-01 |
| 卷号 | 176期号:7页码:663-671 |
| 关键词 | basal metabolic rate (BMR) leptin nonshivering thermogenesis (NST) root vole (Microtus oeconomus) uncoupling protein 1 (UCP1) |
| 合作状况 | 其它 |
| 中文摘要 | survival of small mammals in winter requires proper adjustments in physiology, behavior and morphology. the present study was designed to examine the changes in serum leptin concentration and the molecular basis of thermogenesis in seasonally acclimatized root voles (microtus oeconomus) from the qinghai-tibetan plateau. in january root voles had lower body mass and body fat mass coupled with higher nonshivering thermogenesis (nst) capacity. consistently, cytochrome c oxidase activity and mitochondrial uncoupling protein-1 (ucp1) protein contents in brown adipose tissues were higher in january as compared to that in july. circulating level of serum leptin was significantly lower in winter and higher in july. correlation analysis showed that serum leptin levels were positively related with body mass and body fat mass while negatively correlated with ucp1 protein contents. together, these data provided further evidence for our previous findings that root voles from the qinghai-tibetan plateau mainly depend on higher nst coupled with lower body mass to enhance winter survival. further, fat deposition was significantly mobilized in cold winter and leptin was potentially involved in the regulation of body mass and thermogenesis in root voles. serum leptin might act as a starvation signal in winter and satiety signal in summer. |
| 英文摘要 | survival of small mammals in winter requires proper adjustments in physiology, behavior and morphology. the present study was designed to examine the changes in serum leptin concentration and the molecular basis of thermogenesis in seasonally acclimatized root voles (microtus oeconomus) from the qinghai-tibetan plateau. in january root voles had lower body mass and body fat mass coupled with higher nonshivering thermogenesis (nst) capacity. consistently, cytochrome c oxidase activity and mitochondrial uncoupling protein-1 (ucp1) protein contents in brown adipose tissues were higher in january as compared to that in july. circulating level of serum leptin was significantly lower in winter and higher in july. correlation analysis showed that serum leptin levels were positively related with body mass and body fat mass while negatively correlated with ucp1 protein contents. together, these data provided further evidence for our previous findings that root voles from the qinghai-tibetan plateau mainly depend on higher nst coupled with lower body mass to enhance winter survival. further, fat deposition was significantly mobilized in cold winter and leptin was potentially involved in the regulation of body mass and thermogenesis in root voles. serum leptin might act as a starvation signal in winter and satiety signal in summer. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 动物学 |
| 类目[WOS] | physiology ; zoology |
| 研究领域[WOS] | physiology ; zoology |
| 关键词[WOS] | non-shivering thermogenesis ; pikas ochotona-curzoniae ; nonshivering thermogenesis ; short photoperiod ; body-weight ; djungarian hamster ; golden-hamsters ; metabolic-rate ; brandts voles ; cold |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240018800007 |
| 公开日期 | 2009-12-08 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/1321]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100080, Peoples R China 2.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810001, Qinghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jian-Mei,Zhang, Yan-Ming,Wang, De-Hua. Seasonal regulations of energetics, serum concentrations of leptin, and uncoupling protein 1 content of brown adipose tissue in root voles (Microtus oeconomus) from the Qinghai-Tibetan plateau[J]. journal of comparative physiology b-biochemical systemic and environmental physiology,2006,176(7):663-671. |
| APA | Wang, Jian-Mei,Zhang, Yan-Ming,&Wang, De-Hua.(2006).Seasonal regulations of energetics, serum concentrations of leptin, and uncoupling protein 1 content of brown adipose tissue in root voles (Microtus oeconomus) from the Qinghai-Tibetan plateau.journal of comparative physiology b-biochemical systemic and environmental physiology,176(7),663-671. |
| MLA | Wang, Jian-Mei,et al."Seasonal regulations of energetics, serum concentrations of leptin, and uncoupling protein 1 content of brown adipose tissue in root voles (Microtus oeconomus) from the Qinghai-Tibetan plateau".journal of comparative physiology b-biochemical systemic and environmental physiology 176.7(2006):663-671. |
入库方式： OAI收割
来源：西北高原生物研究所
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