Hypoxia-inducible factor 1 alpha cDNA cloning and its mRNA and protein tissue specific expression in domestic yak (Bos grunniens) from Qinghai-Tibetan plateau
文献类型：期刊论文
| 作者 | Wang, D. P.; Li, H. G.; Li, Y. J.; Guo, S. C.; Yang, J.; Qi, D. L.; Jin, C.; Zhao, X. Q. |
| 刊名 | biochemical and biophysical research communications
 |
| 出版日期 | 2006-09-15 |
| 卷号 | 348期号:1页码:310-319 |
| 关键词 | Qinghai-Tibetan plateau domestic yak hypoxia HIF-1 alpha isoform mRNA protein |
| 合作状况 | 其它 |
| 中文摘要 | adaptation to hypoxia is regulated by hypoxia-inducible factor 1 (hif-1), a heterodimeric transcription factor consisting of an oxygen-regulated a-subunit and a constitutively expressed beta-subunit. how animals living on qinghai-tibetan plateau adapt to the extreme hypoxia environment is known indistinctly. in this study, the qinghai yak which has been living at 3000-5000 m attitude for at least two millions of years was selected as the model of high hypoxia-tolerant adaptation species. the hif-1 alpha orfs (open reading frames) encoding for two isoforms of hif-1 alpha have been cloned from the brain of the domestic yak. its expression of hif-1 alpha was analyzed at both mrna and protein levels in various tissues. both its hif-1 alpha mrna and protein are tissue specific expression. its hif-1 alpha protein's high expression in the brain, lung, and kidney showed us that hif-1 alpha protein may play an important role in the adaptation to hypoxia environment. (c) 2006 elsevier inc. all rights reserved. |
| 英文摘要 | adaptation to hypoxia is regulated by hypoxia-inducible factor 1 (hif-1), a heterodimeric transcription factor consisting of an oxygen-regulated a-subunit and a constitutively expressed beta-subunit. how animals living on qinghai-tibetan plateau adapt to the extreme hypoxia environment is known indistinctly. in this study, the qinghai yak which has been living at 3000-5000 m attitude for at least two millions of years was selected as the model of high hypoxia-tolerant adaptation species. the hif-1 alpha orfs (open reading frames) encoding for two isoforms of hif-1 alpha have been cloned from the brain of the domestic yak. its expression of hif-1 alpha was analyzed at both mrna and protein levels in various tissues. both its hif-1 alpha mrna and protein are tissue specific expression. its hif-1 alpha protein's high expression in the brain, lung, and kidney showed us that hif-1 alpha protein may play an important role in the adaptation to hypoxia environment. (c) 2006 elsevier inc. all rights reserved. |
| 学科主题 | 生物化学 |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; biophysics |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics |
| 关键词[WOS] | pulmonary arterial-hypertension ; high-altitude ; nitric-oxide ; factor hif-1-alpha ; factor-i ; hif-1 ; induction ; o-2 ; quantification ; erythropoietin |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239796100043 |
| 公开日期 | 2009-12-08 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/1323]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100080, Peoples R China 2.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810001, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, D. P.,Li, H. G.,Li, Y. J.,et al. Hypoxia-inducible factor 1 alpha cDNA cloning and its mRNA and protein tissue specific expression in domestic yak (Bos grunniens) from Qinghai-Tibetan plateau[J]. biochemical and biophysical research communications,2006,348(1):310-319. |
| APA | Wang, D. P..,Li, H. G..,Li, Y. J..,Guo, S. C..,Yang, J..,...&Zhao, X. Q..(2006).Hypoxia-inducible factor 1 alpha cDNA cloning and its mRNA and protein tissue specific expression in domestic yak (Bos grunniens) from Qinghai-Tibetan plateau.biochemical and biophysical research communications,348(1),310-319. |
| MLA | Wang, D. P.,et al."Hypoxia-inducible factor 1 alpha cDNA cloning and its mRNA and protein tissue specific expression in domestic yak (Bos grunniens) from Qinghai-Tibetan plateau".biochemical and biophysical research communications 348.1(2006):310-319. |
入库方式： OAI收割
来源：西北高原生物研究所
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