Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii
文献类型：期刊论文
| 作者 | Pan, Li; Zhou, Ping; Zhang, Xiaofeng; Peng, Shulin; Ding, Lisheng; Qiu, Samuel X. |
| 刊名 | organic letters
 |
| 出版日期 | 2006-06-22 |
| 卷号 | 8期号:13页码:2775-2778 |
| 合作状况 | 其它 |
| 中文摘要 | two novel rearranged trachylobane diterpenoids, designated as wallichanol a (2) and wallichanol b (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of euphorbia wallichii. their structures were elucidated by comprehensive analysis of 2d-nmr spectroscopic data, with the stereochemistry of 1 confirmed by x-ray crystallographic study. all of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis. |
| 英文摘要 | two novel rearranged trachylobane diterpenoids, designated as wallichanol a (2) and wallichanol b (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of euphorbia wallichii. their structures were elucidated by comprehensive analysis of 2d-nmr spectroscopic data, with the stereochemistry of 1 confirmed by x-ray crystallographic study. all of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 生物科学 |
| 类目[WOS] | chemistry, organic |
| 研究领域[WOS] | chemistry |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000238284500030 |
| 公开日期 | 2009-12-08 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/1325]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China 2.Washington Univ, Sch Med, St Louis, MO 63110 USA 3.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Li,Zhou, Ping,Zhang, Xiaofeng,et al. Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii[J]. organic letters,2006,8(13):2775-2778. |
| APA | Pan, Li,Zhou, Ping,Zhang, Xiaofeng,Peng, Shulin,Ding, Lisheng,&Qiu, Samuel X..(2006).Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.organic letters,8(13),2775-2778. |
| MLA | Pan, Li,et al."Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii".organic letters 8.13(2006):2775-2778. |
入库方式： OAI收割
来源：西北高原生物研究所
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